{ "id": "2026-W28", "year": 2026, "week": 28, "week_monday": "2026-07-06", "week_sunday": "2026-07-12", "asof": "2026-07-12", "window_start": "2026-07-06", "window_end": "2026-07-12", "window_days": 7, "widened": false, "strict_study_count": 33, "strict_trial_count": 0, "study_count": 33, "trial_count": 0, "studies": { "long-covid": [ { "pmid": "42409185", "title": "Temelimab versus placebo in patients with post-COVID condition.", "journal": "Brain, behavior, and immunity", "pub_date": "2026-07-07", "authors": "Nehme, Mayssam, Hund-Georgiadis, Margret, Corral Beamonte, Esther Del, Bridevaux, Pierre-Olivier et al.", "excerpt": "More than 400 million individuals are estimated to have been affected by post-COVID condition or long COVID. This condition can lead to significantly decreased quality of life and increased individual and societal costs.", "url": "https://pubmed.ncbi.nlm.nih.gov/42409185/", "also": [] }, { "pmid": "42409655", "title": "Post-acute sequelae of COVID in children: Pulmonary assessment using impulse oscillometry and the effect of vaccination.", "journal": "Pediatrics and neonatology", "pub_date": "2026-07-07", "authors": "Chen, Chieh-Ho, Chen, Pei-Chi, Liu, Xiao-Ling, Wei, Chi-Hung et al.", "excerpt": "Post-acute sequelae of SARS-CoV-2 infection (PASC), also known as long COVID syndrome (LCS), is characterized by persistent symptoms following SARS-CoV-2 infection and poses significant health challenges, particularly impacting pulmonary function in children. This study aims to evaluate the effect of COVID-19 vaccination on pulmonary function in children with PASC using standardized spirometry and impulse...", "url": "https://pubmed.ncbi.nlm.nih.gov/42409655/", "also": [] }, { "pmid": "42409265", "title": "Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo.", "journal": "The Journal of biological chemistry", "pub_date": "2026-07-07", "authors": "Natarajan, Niranjana, Ahmed, Thaybah, Govindaswamy, Balaji, Manickam, Devika S et al.", "excerpt": "Macrophages are versatile immune cells, with the ability to respond to varied intrinsic and extrinsic cues, and transition between inflammatory and pro-reparative phenotypes. A complex network of epigenetic processes, such as DNA methylation, and histone methylation and acetylation, plays key roles in modulating macrophage polarization and inflammatory gene expression.", "url": "https://pubmed.ncbi.nlm.nih.gov/42409265/", "also": [] }, { "pmid": "42402260", "title": "Time to Recovery from Long COVID: A Longitudinal Analysis of Symptom Duration and Risk Factors Using Accelerated Failure Time Models.", "journal": "International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases", "pub_date": "2026-07-06", "authors": "Jo, Youngji, Hu, Zeyu, Joo, Hyejin, Jung, Jaehun et al.", "excerpt": "Long COVID comprises heterogeneous symptoms that may persist for months to years after acute SARS-CoV-2 infection. While prevalence is well described, less is known about symptom duration and determinants of recovery.", "url": "https://pubmed.ncbi.nlm.nih.gov/42402260/", "also": [] }, { "pmid": "42403350", "title": "Regional Disparities in Functional and Socioeconomic Impacts of Long COVID in Brazil: A Cross-Sectional Observational Study.", "journal": "Physiotherapy research international : the journal for researchers and clinicians in physical therapy", "pub_date": "2026-07-06", "authors": "Dos Santos, Ana Cleides Pereira, Goulart, Cássia da Luz, Neves, Victor Ribeiro, Milani, Mauricio et al.", "excerpt": "In low- and middle-income countries such as Brazil, regional inequalities in healthcare access and socioeconomic conditions may exacerbate the functional and occupational consequences of Long COVID. This study explored between-center differences in functional and socioeconomic outcomes among individuals with Long COVID from three Brazilian centers in Brazil, while examining how these findings may have been...", "url": "https://pubmed.ncbi.nlm.nih.gov/42403350/", "also": [] }, { "pmid": "42406399", "title": "Postacute COVID-19 Symptoms and Health Care Utilization and Spending Among Traditional Medicare Beneficiaries.", "journal": "JAMA network open", "pub_date": "2026-07-06", "authors": "Ghosh, Kaushik, Zuckerman, Rachael, Feyman, Yevgeniy, Orav, E John et al.", "excerpt": "Postacute sequelae of SARS-CoV-2 infection include fatigue, respiratory symptoms, and cognitive dysfunction. However, the extent to which these symptoms contribute to increased health care utilization and spending among Medicare beneficiaries remains unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42406399/", "also": [] }, { "pmid": "42403377", "title": "Post-COVID paediatric dysautonomia: never the heart, always the brain-myth or maxim?", "journal": "Cardiology in the young", "pub_date": "2026-07-06", "authors": "Das, Bibhuti, Moodley, Manikum", "excerpt": "Paediatric dysautonomia has become increasingly recognised in children and adolescents, particularly in the post-COVID era. Affected patients commonly present with dizziness, palpitations, exercise intolerance, fatigue, and syncope, although reported prevalence varies widely because of evolving definitions and heterogeneous referral patterns.", "url": "https://pubmed.ncbi.nlm.nih.gov/42403377/", "also": [ "pots" ] }, { "pmid": "42404887", "title": "Mechanisms and impact of long COVID: pathophysiology, neuropsychiatric effects and vaccination.", "journal": "Frontiers in immunology", "pub_date": "2026-07-06", "authors": "Ponnachan, Pretty, Dhawlarker, Anam, Yasmin, Hadida, Shah, Akash et al.", "excerpt": "Long COVID or post-acute sequelae of COVID-19 is defined as an after-effect of acute COVID-19 infection. Its broad clinical symptoms include brain fog, shortness of breath, fatigue, joint, chest, or muscle pain, dysautonomia and neuropsychiatric symptoms such as anxiety, depression and post-traumatic stress disorder.", "url": "https://pubmed.ncbi.nlm.nih.gov/42404887/", "also": [] }, { "pmid": "42407187", "title": "Jianpi Huayu decoction alleviates hepatic fibrosis involving coordinated modulation of PPARα-mediated lipid metabolic reprogramming and the ROCK pathway.", "journal": "Phytomedicine : international journal of phytotherapy and phytopharmacology", "pub_date": "2026-07-06", "authors": "Luo, Rui, Lai, Yongheng, Zhang, Sijia, Yao, Ruiwei et al.", "excerpt": "Hepatic fibrosis is a critical stage in the progression from chronic liver injury to hepatocellular carcinoma (HCC), yet effective therapeutic options remain limited. Jianpi Huayu Decoction (JPHY) has been used clinically in patients with HCC accompanied by hepatic fibrosis, but its anti-fibrotic mechanisms remain unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42407187/", "also": [] }, { "pmid": "42406565", "title": "Evaluation of nirmatrelvir/ritonavir treatment for COVID-19 on health-related outcomes: a global economic value systematic literature review.", "journal": "Journal of medical economics", "pub_date": "2026-07-06", "authors": "Mugwagwa, Tendai, Marcano Belisario, José, Hartley, Louise, Phan, Nguyen Thi Nhan et al.", "excerpt": "Nirmatrelvir/ritonavir (NMV/r) A systematic search of Embase, PubMed, Cochrane, and EconLit and of conference and health technology assessment agency websites was performed to identify economic analyses published between January 2022 and October 2025. Of the 33 included economic evaluations, most were cost-utility analyses ( Most studies were conducted in high-income countries, were based on different COVID-19...", "url": "https://pubmed.ncbi.nlm.nih.gov/42406565/", "also": [] } ], "me-cfs": [ { "pmid": "42403482", "title": "Disrupted glymphatic function and its relationship with sleep and cognitive impairment in ME/CFS assessed via DTI-ALPS.", "journal": "Frontiers in neuroscience", "pub_date": "2026-07-06", "authors": "Thapaliya, Kiran, Marshall-Gradisnik, Sonya, Inderyas, Maira, Barnden, Leighton", "excerpt": "The glymphatic system is a recently discovered brain waste clearance system that is mostly active during sleep and disengaged during wakefulness. Impaired glymphatic function leads to the deposition of metabolic waste products in the brain potentially causing inflammation leading to various symptoms in ME/CFS.", "url": "https://pubmed.ncbi.nlm.nih.gov/42403482/", "also": [] }, { "pmid": "42404713", "title": "Cognitive impairment and prefrontal TGF-β1 elevation in a rat model of fatigue.", "journal": "Frontiers in psychiatry", "pub_date": "2026-07-06", "authors": "Wu, Yingru, Wen, Xuan, Fang, Zeman, Zhang, Jinling et al.", "excerpt": "Chronic fatigue syndrome (CFS) is a complex disorder of unknown etiology, characterized by persistent fatigue unrelieved by rest and accompanied by cognitive dysfunction. While dysregulated cytokines are implicated in CFS pathogenesis, the role of anti-inflammatory transforming growth factor β1 (TGF-β1) remains poorly defined.", "url": "https://pubmed.ncbi.nlm.nih.gov/42404713/", "also": [] } ], "pacvs": [], "lyme": [], "gulf-war-illness": [], "pots": [ { "pmid": "42419817", "title": "Author Response to \"Dysautonomia in Long COVID: Why Sex Differences Matter in Cardiovascular Risk Assessment\".", "journal": "Clinical medicine & research", "pub_date": "2026-07-09", "authors": "Tamariz, Leonardo, Palacio, Ana", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42419817/", "also": [] }, { "pmid": "42415471", "title": "Safety monitoring of bivalent, quadrivalent, and 9-valent human papillomavirus vaccination in Japan: The vaccine effectiveness, networking, and universal safety (VENUS) study.", "journal": "Human vaccines & immunotherapeutics", "pub_date": "2026-07-08", "authors": "Ishiguro, Chieko, Morita, Hiroya, Mimura, Wataru, Tsuzuki, Shinya et al.", "excerpt": "Safety data on human papillomavirus (HPV) vaccination in the Japanese population remain limited owing to the lack of healthcare databases available for vaccine safety assessment. In this study, we assessed the risk of adverse events of special interest (AESIs) following HPV vaccination among females aged 12-26 y using medical claims data linked to routine or catch-up vaccination records provided by municipalities.", "url": "https://pubmed.ncbi.nlm.nih.gov/42415471/", "also": [] }, { "pmid": "42412583", "title": "Prolonged rhythmic mid-temporal theta of drowsiness in a patient with postural orthostatic tachycardia syndrome: A diagnostic challenge.", "journal": "Epileptic disorders : international epilepsy journal with videotape", "pub_date": "2026-07-07", "authors": "Sun, Ruiqing L, Valaparla, Vijaya, Reiley, Luz Elena", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42412583/", "also": [] }, { "pmid": "42411507", "title": "Ivabradine in the Treatment of POTS Before and After COVID-19 Pandemic: A Systematic Review and Meta-Analysis.", "journal": "Journal of cardiovascular pharmacology", "pub_date": "2026-07-07", "authors": "Qadri, Syeda Hafsa, Nardelli da Silva, Ana Beatriz, Malaj, Andela, Ahmed, Rohma et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is a debilitating autonomic disorder characterized by excessive orthostatic tachycardia and significant functional impairment. Conventional therapies, including beta-blockers, often provide incomplete relief or are poorly tolerated.", "url": "https://pubmed.ncbi.nlm.nih.gov/42411507/", "also": [] } ], "mcas": [ { "pmid": "42430077", "title": "Targeting IL-33 in Precision Neuroimmunology: Cellular Mechanisms and Therapeutic Strategies for CNS Disorders.", "journal": "Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology", "pub_date": "2026-07-10", "authors": "Li, Lili, Wang, Shuting, Duan, Lian, Zhang, Luyu et al.", "excerpt": "Interleukin-33 (IL-33), an alarmin cytokine of the IL-1 family, has emerged as a pivotal regulator of neuroimmune interactions in the central nervous system (CNS). Acting through its receptor ST2, IL-33 orchestrates diverse immune responses by modulating microglial polarization, shaping T cell differentiation, activating type 2 innate lymphoid cells (ILC2s), and engaging mast cell-macrophage regulatory circuits.", "url": "https://pubmed.ncbi.nlm.nih.gov/42430077/", "also": [] }, { "pmid": "42425799", "title": "Phenotype-specific associations of mosaic chromosomal alterations in systemic sclerosis.", "journal": "Annals of the rheumatic diseases", "pub_date": "2026-07-10", "authors": "Nishio, Yuki, Ishikawa, Yuki, Uchiyama, Shunsuke, Liu, Xiaoxi et al.", "excerpt": "Mosaic chromosomal alterations (mCAs) increase with age and are associated with many diseases, including autoimmune diseases. The associations between mCAs and systemic sclerosis (SSc) and its clinical subtypes have not been explored.", "url": "https://pubmed.ncbi.nlm.nih.gov/42425799/", "also": [] }, { "pmid": "42424794", "title": "Pharmacological modulation of TRPV2 enhances migration and induces Immunoglobulin E (IgE)-independent degranulation of mast cells.", "journal": "Cell calcium", "pub_date": "2026-07-10", "authors": "Leipe, Andrea, Raudszus, Rick, Urban, Nicole, Schaefer, Michael et al.", "excerpt": "Transient receptor potential vanilloid 2 (TRPV2) is highly expressed in immune cells, including mast cells, yet its functional role in mast cell physiology remains incompletely understood. Given the increasing global prevalence of immune disorders, elucidating TRPV2-mediated mechanisms may uncover novel therapeutic approaches.", "url": "https://pubmed.ncbi.nlm.nih.gov/42424794/", "also": [] }, { "pmid": "42428085", "title": "Hematopoietic mosaic chromosomal alterations are pleiotropic drivers of inflammaging, multimorbidity, and mortality.", "journal": "medRxiv : the preprint server for health sciences", "pub_date": "2026-07-10", "authors": "Vincelette, Nicole D, Mo, Qianxing, Cheng, Chia-Ho, Park, Junyoung et al.", "excerpt": "Mosaic chromosomal alterations (mCAs) are a prevalent but poorly understood form of clonal hematopoiesis (CH). Whether mCAs contribute to disease independently of CHIP, and whether their large-scale genomic effects can be resolved to actionable targets, remain unknown.", "url": "https://pubmed.ncbi.nlm.nih.gov/42428085/", "also": [] }, { "pmid": "42423275", "title": "Topical Trichosanthis Radix Water Extract Attenuates Atopic Dermatitis-Like Skin Inflammation: Marker Standardization, Network Pharmacology, and Preclinical Validation.", "journal": "Mediators of inflammation", "pub_date": "2026-07-09", "authors": "Kim, Hye-Min, Kim, Geun-Lip, Gil, Tae-Young, Sim, Ha-Yeon et al.", "excerpt": "Trichosanthis Radix (TR) is a pharmacopeial crude drug traditionally used to clear heat, reduce swelling, expel pus, and generate fluids, suggesting potential relevance to inflammatory skin disorders such as atopic dermatitis (AD). In this study, we evaluated the AD-related activity of a TR water extract using an integrated workflow combining network-based target analysis, marker compound analysis, and experimental...", "url": "https://pubmed.ncbi.nlm.nih.gov/42423275/", "also": [] }, { "pmid": "42423558", "title": "Origami Metamaterials Based on Low-Melting-Point Alloy Phase Transition: Breaking the Trade-Off Between Reusability and Energy Absorption Quality.", "journal": "Advanced science (Weinheim, Baden-Wurttemberg, Germany)", "pub_date": "2026-07-09", "authors": "Liu, Yupeng, Zhao, Wei, Zeng, Chengjun, Fan, Jiuming et al.", "excerpt": "Mechanical metamaterials provide a promising platform for designing energy-absorbing materials. However, the trade-off between reusability and energy absorption quality limits the overall performance of existing energy-absorbing metamaterials.", "url": "https://pubmed.ncbi.nlm.nih.gov/42423558/", "also": [] }, { "pmid": "42421939", "title": "New-onset allergic diseases after SARS-CoV-2 infection: mechanistic hypotheses and emerging strategies for risk stratification.", "journal": "Frontiers in immunology", "pub_date": "2026-07-09", "authors": "Li, Encheng, Shi, Manying, Huang, Shixiang", "excerpt": "Multinational cohort studies consistently associate SARS-CoV-2 infection with elevated incidence of allergic diseases, with hazard ratios of 2.25 for asthma and 1.23 for allergic rhinitis persisting beyond six months post-infection; whether this excess risk reflects", "url": "https://pubmed.ncbi.nlm.nih.gov/42421939/", "also": [] }, { "pmid": "42424102", "title": "Dual-Site-Binding Ligand-Driven (100) Orientation for Efficient and Stable Perovskite Solar Cells.", "journal": "Advanced materials (Deerfield Beach, Fla.)", "pub_date": "2026-07-09", "authors": "Lv, Dongyang, Wang, Cheng, Li, Luyao, Chu, Weicun et al.", "excerpt": "Regulating crystal orientation is a powerful strategy for enhancing the optoelectronic performance of perovskite solar cells (PSCs). However, most existing approaches rely on single-site ligand binding, which not only forms insulating layers that hinder charge transport but also involves weak coordination that limits orientation control.", "url": "https://pubmed.ncbi.nlm.nih.gov/42424102/", "also": [] }, { "pmid": "42419153", "title": "Caffeic acid attenuates stress-induced colon inflammation and barrier disruption in Sprague-Dawley rats.", "journal": "Cytokine", "pub_date": "2026-07-09", "authors": "Mazumder, Sangita, Dubey, Itishree, Gupta, Arushi, Bhardwaj, Shivani et al.", "excerpt": "Chronic stress promotes colonic inflammation by sustaining activation of the hypothalamic-pituitary-adrenal (HPA) axis, inducing oxidative stress, and disrupting barrier integrity, thereby exacerbating inflammatory bowel disease and irritable bowel syndrome. Therefore, there is a need for therapeutic compounds that can ameliorate stress-induced colonic inflammation.", "url": "https://pubmed.ncbi.nlm.nih.gov/42419153/", "also": [] }, { "pmid": "42413736", "title": "Revisiting pharmacological actions of disodium cromoglycate in light of GPR35: New therapeutic contexts for classical drugs.", "journal": "Biochemical pharmacology", "pub_date": "2026-07-08", "authors": "Tanaka, Satoshi", "excerpt": "Mast cell stabilizers such as disodium cromoglycate have been used for decades as prophylactic anti-allergic agents, yet their molecular targets remained unknown, and their intracellular mechanisms were long debated. Identification of GPR35 as a receptor engaged by multiple mast cell stabilizers provided a new framework to reinterpret classical pharmacology.", "url": "https://pubmed.ncbi.nlm.nih.gov/42413736/", "also": [] }, { "pmid": "42414303", "title": "Primary sclerosing cholangitis displays distinct colonic mucosa topography yet a shared mast cell state with ulcerative colitis.", "journal": "Nature communications", "pub_date": "2026-07-08", "authors": "Tearle, Jacqueline LE, Sviriaeva, Ekaterina, Zhang, Fan, Jackson, Katherine Jl et al.", "excerpt": "Primary sclerosing cholangitis (PSC) is a chronic, progressing cholestatic disease that often co-occurs with inflammatory bowel disease (PSC-IBD). PSC-IBD affecting the colon (PSC-ulcerative colitis or PSC-UC) resembles clinical UC, but is characterised by less severe disease flares, right-colon predominance, and a greater lifetime risk of colorectal cancer than UC alone.", "url": "https://pubmed.ncbi.nlm.nih.gov/42414303/", "also": [] }, { "pmid": "42418669", "title": "Mast cell-derived IL-13 as a driver of Crohn disease-associated intestinal fibrosis.", "journal": "Inflammatory bowel diseases", "pub_date": "2026-07-08", "authors": "Safari, Kwestan, Ma, Wei Jen, Sekhon, Prabhreet, Rai, Priya et al.", "excerpt": "Crohn disease is a chronic, immune-mediated disease that can lead to intestinal fibrosis, strictures, and bowel obstruction. The Src homology 2 domain-containing inositol polyphosphate 5'-phosphatase-deficient (SHIP-/-) mouse develops spontaneous Crohn disease-like ileal inflammation and fibrosis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42418669/", "also": [] }, { "pmid": "42413737", "title": "Activation of GABA", "journal": "Biochemical pharmacology", "pub_date": "2026-07-08", "authors": "Xie, Haoxian, Liu, Huilin, Xiu, Yixin, Lao, Rongkang et al.", "excerpt": "Although the metabotropic GABA type B receptor (GABA", "url": "https://pubmed.ncbi.nlm.nih.gov/42413737/", "also": [] }, { "pmid": "42406837", "title": "The scaffolding protein AKAP79/150 shapes innate immune responses to allergen.", "journal": "Journal of immunology (Baltimore, Md. : 1950)", "pub_date": "2026-07-06", "authors": "Kaur, Suneet, Lin, Yu-Ping, Nakano, Hideki, Brown, Paula et al.", "excerpt": "Inhalation of house dust mite-derived allergens is a major factor leading to the development of asthma both in children and adults. Allergens stimulate Ca2+-dependent pro-inflammatory cytokine and chemokine gene expression through the opening of ORAI1 Ca2+ channels in the surface membrane of various immune cell-types within the lung.", "url": "https://pubmed.ncbi.nlm.nih.gov/42406837/", "also": [] }, { "pmid": "42405823", "title": "Mast cell activation disorders: mechanisms, comorbidities and look alike.", "journal": "Expert review of clinical immunology", "pub_date": "2026-07-06", "authors": "Theoharides, Theoharis C, Kempuraj, Duraisamy, Maitland, Anne", "excerpt": "Mast Cells (MCs) are unique tissue immune cells found perivascularly close to nerves at interfaces with the external environment. Upon detection of danger signals, MCs act as master responders aiming to restore homeostasis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42405823/", "also": [] }, { "pmid": "42403014", "title": "Dendritic Cell α-Ketoglutarate Regulates Tfh Polarization in Allergy.", "journal": "Allergy", "pub_date": "2026-07-06", "authors": "Tharakan, Anuj, Qu, Xufeng, Camarena, Carmen, Abaidoo-Myles, Araba et al.", "excerpt": "Initiation of allergic responses requires activation of specialized subsets of T follicular helper (Tfh) cells called Tfh13 cells. Differentiation of these cells from naïve CD4", "url": "https://pubmed.ncbi.nlm.nih.gov/42403014/", "also": [] }, { "pmid": "42404753", "title": "Cpg boosts peptide-based oral immunotherapy in mice with peanut allergy.", "journal": "Frontiers in allergy", "pub_date": "2026-07-06", "authors": "Liu, Fang, Yang, Jun-Hui, Han, Lei, Liu, Qiao et al.", "excerpt": "Effective therapies for peanut allergy (PA) remain limited. Cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODN) have emerged as promising adjuvants for allergen-specific immunotherapy (AIT).", "url": "https://pubmed.ncbi.nlm.nih.gov/42404753/", "also": [] } ], "other-post-viral": [] }, "trials": [], "feed_latest_pub_date": "2026-07-10", "numbers": { "studies_tracked": 544, "trials_tracked": 620, "biomarkers_catalogued": 546, "feeds": 8 }, "feed_updates": { "long-covid": "2026-07-07", "me-cfs": "2026-07-06", "pacvs": "2026-06-25", "lyme": "2026-07-08", "gulf-war-illness": "2026-07-09", "pots": "2026-07-10", "mcas": "2026-07-10", "other-post-viral": "2026-06-25" }, "trials_last_run": "2026-06-26", "generated_at": "2026-10-07T22:29:14+00:00" }