{ "id": "2026-W26", "year": 2026, "week": 26, "week_monday": "2026-06-22", "week_sunday": "2026-06-28", "asof": "2026-06-28", "window_start": "2026-06-22", "window_end": "2026-06-28", "window_days": 7, "widened": false, "strict_study_count": 45, "strict_trial_count": 9, "study_count": 45, "trial_count": 9, "studies": { "long-covid": [ { "pmid": "42364998", "title": "Systemic atopy and upper-airway disease define susceptibility to incident asthma after COVID-19 in Korea.", "journal": "Nature communications", "pub_date": "2026-06-28", "authors": "Choi, You-Jung, Kim, Young-Chan, Bea, Sungho, Shin, Ju-Young et al.", "excerpt": "Incident asthma is an important respiratory sequela after COVID-19, but it is unclear which allergic phenotypes amplify risk. Using a linked nationwide Korean database of 3,987,182 individuals with confirmed severe acute respiratory syndrome coronavirus 2 infection, we compare claims-based incident asthma in those with pre-existing systemic atopy and/or upper-airway disease (allergic rhinitis, chronic...", "url": "https://pubmed.ncbi.nlm.nih.gov/42364998/", "also": [] }, { "pmid": "42364466", "title": "Artificial intelligence-enhanced nurse navigation for monitoring and care of long COVID.", "journal": "International journal of medical informatics", "pub_date": "2026-06-28", "authors": "Bandeira Barboza, Ana Paula, Monteiro, Renata Luciria, Muschi, Alessandra Luna, Dos Santos Silva et al.", "excerpt": "Long COVID is a multisystem condition with challenging diagnosis. Nurse-navigation, a patient-centered intervention, can enhance education and care access.", "url": "https://pubmed.ncbi.nlm.nih.gov/42364466/", "also": [] }, { "pmid": "42362344", "title": "The efficacy of conventional chest physiotherapy in managing acute hypoxaemic respiratory failure.", "journal": "BMJ case reports", "pub_date": "2026-06-27", "authors": "Deshmukh, Mayura, Vishwakarma, Janvi Chandrasen, Chitale, Neha, Palekar, Tushar", "excerpt": "A man in his 60s presented with acute hypoxaemic respiratory failure secondary to post-COVID-19 fibrotic pneumonia, requiring 3 L/min oxygen therapy (peripheral oxygen saturation (SpO", "url": "https://pubmed.ncbi.nlm.nih.gov/42362344/", "also": [] }, { "pmid": "42362970", "title": "SARS-CoV-2 and diabetes: a post-pandemic reappraisal.", "journal": "Diabetologia", "pub_date": "2026-06-27", "authors": "Said, Noora, Jones, Ian, Anderson-Baucum, Emily K, Evans-Molina, Carmella", "excerpt": "The COVID-19 pandemic was a dynamic and often confusing period for clinical and biomedical research. As severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spread globally, knowledge accumulated rapidly through publications that were frequently based on preliminary or sometimes conflicting evidence, yet these papers played a critical role in shaping evolving medical, research and societal responses.", "url": "https://pubmed.ncbi.nlm.nih.gov/42362970/", "also": [] }, { "pmid": "42363551", "title": "Genetic evidence that advanced COVID-19 accelerates longitudinal brain atrophy: A Mendelian randomization study.", "journal": "Medicine", "pub_date": "2026-06-27", "authors": "Wen, Jie, Chen, Yuyao, Zhang, Jingwei, Tan, Zeming et al.", "excerpt": "Coronavirus disease 2019 (COVID-19) was reported to persist long-term in the brain and leave several long-term neurologic sequelae. However, the causal relationship between COVID-19 and brain aging is still unknown.", "url": "https://pubmed.ncbi.nlm.nih.gov/42363551/", "also": [] }, { "pmid": "42363216", "title": "Bronchovascular texture pattern on quantitative CT reveals airway and vascular remodeling in post-COVID-19 Lungs.", "journal": "Respiratory research", "pub_date": "2026-06-27", "authors": "Zhang, Xuan, Rajaraman, Prathish K, Comellas, Alejandro P, Hoffman, Eric A et al.", "excerpt": "The long-term consequences of COVID-19 remain poorly understood. To assess CT image-based biomarkers and clinical symptoms in COVID-19 survivors approximately 3-4 years after infection.", "url": "https://pubmed.ncbi.nlm.nih.gov/42363216/", "also": [] }, { "pmid": "42363213", "title": "A qualitative study of the impact of the COVID-19 pandemic on healthcare access and service delivery for people living with chronic obstructive pulmonary disease and asthma.", "journal": "Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology", "pub_date": "2026-06-27", "authors": "Brehon, Katelyn, Choi, Mirsol, Hung, Pam, Miciak, Maxi et al.", "excerpt": "Incidence of chronic obstructive pulmonary disease and asthma diagnosis were lower during and after the Coronavirus disease 2019 pandemic in Alberta, Canada. However, it is unknown whether incidences were actually lower or if the pandemic created circumstances where patients did not seek care.", "url": "https://pubmed.ncbi.nlm.nih.gov/42363213/", "also": [] } ], "me-cfs": [ { "pmid": "42365408", "title": "Effect of \"Tongdu Yupi Tiaoshen\" electroacupuncture on behavioral performance and hippocampal structure and function in chronic fatigue syndrome rats.", "journal": "Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan", "pub_date": "2026-06-28", "authors": "Yuanyuan, Q U, Chuwen, Feng, Weibo, Sun, Yuying, Shao et al.", "excerpt": "To investigate the effects of electroacupuncture intervention on behavioral performance, hippocampal structure, and function in chronic fatigue syndrome (CFS) rats and to explore the underlying mechanisms. Specific pathogen free-grade male Sprague-Dawley rats were randomly allocated into a control group (Con group, Behavioral assessments demonstrated that electroacupuncture intervention significantly improved rat...", "url": "https://pubmed.ncbi.nlm.nih.gov/42365408/", "also": [] }, { "pmid": "42360043", "title": "Comparison of Proteomic Analysis of Cerebrospinal Fluid From Neurological Patients With and Without Amyotrophic Lateral Sclerosis.", "journal": "Journal of neurochemistry", "pub_date": "2026-06-27", "authors": "Sabetta, Eleonora, Rallmann, Karin, Taba, Pille, Pfaff, Abigail L et al.", "excerpt": "Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterised by progressive muscle weakness in both bulbar and extremity muscles, leading to a diverse clinical phenotype with motor and non-motor symptoms. Approximately 85% of ALS cases are sporadic (sALS), while the remaining 10%-15% are familial (fALS).", "url": "https://pubmed.ncbi.nlm.nih.gov/42360043/", "also": [] }, { "pmid": "42358486", "title": "Redefining pandemic resilience: a roadmap for post-infectious syndrome preparedness and health system transformation.", "journal": "Frontiers in health services", "pub_date": "2026-06-26", "authors": "Schieffer, Bernhard", "excerpt": "Post-infectious syndromes like Long COVID and ME/CFS lead to disability and economic losses globally, especially in lower-income countries. These involve complex multisystem issues such as immune disturbances, inflammation, autonomic dysregulation, vascular problems, altered metabolism, and tissue damage.", "url": "https://pubmed.ncbi.nlm.nih.gov/42358486/", "also": [] }, { "pmid": "42356003", "title": "Multimorbidity in Chronic Overlapping Pain Conditions: From Burden to Integrated Care.", "journal": "Journal of clinical medicine", "pub_date": "2026-06-26", "authors": "d'Incau, Emmanuel, Kaplan, Chelsea Marie, Micoulaud-Franchi, Jean-Arthur, Veasley, Christin et al.", "excerpt": "Chronic overlapping pain conditions (COPCs) refer to a set of chronic pain disorders that frequently co-occur and may involve partially overlapping mechanisms. The U.S.", "url": "https://pubmed.ncbi.nlm.nih.gov/42356003/", "also": [] }, { "pmid": "42356126", "title": "Long-Term Follow-Up of Women with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A 16-Year Longitudinal Study.", "journal": "Medicina (Kaunas, Lithuania)", "pub_date": "2026-06-26", "authors": "Tomić, Slavica, Pastornački, Aleksandra, Drljača, Maja, Glogovac, Jelena et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42356126/", "also": [] }, { "pmid": "42357670", "title": "Human Herpesvirus-6A and -6B (HHV-6A and HHV-6B): The Role of Roseoloviruses in Neurological Dysfunction and the Mechanisms of Viral-Induced Epileptogenesis.", "journal": "Viruses", "pub_date": "2026-06-26", "authors": "Bahramian, Elham, Bajpai, Ananya, Yang, Xue, Cairns, Dana M et al.", "excerpt": "Human herpesvirus-6 consists of a pair of viral species, HHV-6A and HHV-6B, which are neurotropic with the ability to invade, persist, and reactivate within the nervous system. Accumulating evidence links HHV-6 to epilepsy and other neuropathologies, including: multiple sclerosis, chronic fatigue syndrome, and neurodegeneration.", "url": "https://pubmed.ncbi.nlm.nih.gov/42357670/", "also": [] }, { "pmid": "42351611", "title": "Comparative Gut Microbiome Alterations in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Long COVID-19 Syndrome.", "journal": "Biomedicines", "pub_date": "2026-06-26", "authors": "Donchev, Deyan, Nikolova, Ralitsa, Vaseva, Katya, Taskov, Hristo et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42351611/", "also": [] }, { "pmid": "42334638", "title": "Effect of photobiomodulation on pain and quality of life in fibromyalgia syndrome: a systematic review.", "journal": "Lasers in medical science", "pub_date": "2026-06-23", "authors": "G A, Swathi, Maiya, G Arun, Shetty, Shiran, Abrahamse, Heidi et al.", "excerpt": "Fibromyalgia Syndrome (FMS) is a chronic pain disorder characterized by widespread pain and central sensitization that significantly impacts the quality of life (QoL). For management to be effective, a multidisciplinary approach to care is typically required.", "url": "https://pubmed.ncbi.nlm.nih.gov/42334638/", "also": [] }, { "pmid": "42325052", "title": "Tryptophan Metabolism and Aryl-Hydrocarbon Receptor Agonists in the Gut Microbiome of People With Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.", "journal": "MicrobiologyOpen", "pub_date": "2026-06-22", "authors": "Esteban, David J, Conrad, Brynn, Cullinan, Autumn, Luong, Sharon et al.", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease with unknown biological basis and no cure. Microbiome dysbiosis has been reported in people with ME/CFS but its relevance to pathophysiology is unknown.", "url": "https://pubmed.ncbi.nlm.nih.gov/42325052/", "also": [] }, { "pmid": "42327760", "title": "Elevated serum levels of interleukin-11 and matrix metalloproteinase-9 in myalgic encephalomyelitis/chronic fatigue syndrome.", "journal": "Frontiers in immunology", "pub_date": "2026-06-22", "authors": "Chinnappan, Baskaran, Kempuraj, Duraisamy, Aenlle, Kristina K, Middleton, Ashley et al.", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a disease of unknown etiology associated with chronic severe fatigue and neurological symptoms, including dizziness, sleep disturbances, cognitive impairment and pain. There are no reliable blood biomarkers available for ME/CFS, possibly due to the lack of specific pathogenesis, even though Epstein-Barr Virus (EBV) has been suspected.", "url": "https://pubmed.ncbi.nlm.nih.gov/42327760/", "also": [] } ], "pacvs": [], "lyme": [ { "pmid": "42359130", "title": "Patient roadmap and economic burden of chronic tick-borne illness and post-treatment Lyme disease syndrome in Ireland, and public health issues arising.", "journal": "Frontiers in public health", "pub_date": "2026-06-26", "authors": "Avramovic, Gordana, Gilbert, Leona, Kujawski, Sławomir, Blehle, Sigrid et al.", "excerpt": "Lyme borreliosis (LB), commonly referred to as Lyme disease (LD), is a prominent global health issue, exhibiting a seroprevalence rate of 14.5%. Heightened incidence levels of LD have been recorded in parts of Europe, Poland, Eastern Europe, and the Baltic States.", "url": "https://pubmed.ncbi.nlm.nih.gov/42359130/", "also": [] }, { "pmid": "42347267", "title": "Anti-", "journal": "Pathogens (Basel, Switzerland)", "pub_date": "2026-06-25", "authors": "Aslan Başbulut, Eşe, Yavuz, Demet, Demir, Tülin", "excerpt": "Lyme borreliosis is a multisystemic tick-borne infection caused by The study included 45 patients and 45 age and sex matched controls. Serum samples were tested for anti- Overall, anti- IgG seropositivity was numerically higher among patients with CKD of unknown etiology than among healthy controls; however, this difference was not statistically significant.", "url": "https://pubmed.ncbi.nlm.nih.gov/42347267/", "also": [] } ], "gulf-war-illness": [ { "pmid": "42347851", "title": "The comparative ameliorating effects of an amorphous formula of curcumin and α-glycosyl isoquercitrin on hippocampal dysfunction in a rat gulf war illness model.", "journal": "Metabolic brain disease", "pub_date": "2026-06-25", "authors": "Tang, Qian, Shobudani, Momoka, Sakamaki, Yuri, Ebizuka, Yuri et al.", "excerpt": "Brain dysfunction is a primary symptom of Gulf War illness (GWI). The present study investigated the effects of an amorphous formula of curcumin (CUR) and α-glycosyl isoquercitrin (AGIQ) on neurobehaviors and adult neurogenesis and following synaptic plasticity of produced neurons in the hippocampal dentate gyrus (DG) in a rat GWI model.", "url": "https://pubmed.ncbi.nlm.nih.gov/42347851/", "also": [] }, { "pmid": "42328091", "title": "\"Treat us Like Human Beings\": Messages and Recommendations to U.S. Policymakers and Veterans Health Administration Providers from a Qualitative Inquiry Into the Health Experiences of Gulf War Veterans With Gulf War Illness.", "journal": "Journal of patient experience", "pub_date": "2026-06-22", "authors": "Montague, Kara A, Lafferty, Megan, Graham, Michael, Nugent, Shannon M", "excerpt": "Gulf War Illness (GWI) affects many U.S. Veterans of the 1990-1991 Persian Gulf War (GWVs), yet recognition of the condition and effective treatments remain limited.", "url": "https://pubmed.ncbi.nlm.nih.gov/42328091/", "also": [] } ], "pots": [ { "pmid": "42342500", "title": "[Cardiorespiratory functional disorders: A transnosologic approach].", "journal": "La Revue de medecine interne", "pub_date": "2026-06-25", "authors": "Ranque, Brigitte, Cathebras, Pascal", "excerpt": "Functional disorders affecting the cardiorespiratory system are common. Non-cardiac chest pain affects more than 10% of the population.", "url": "https://pubmed.ncbi.nlm.nih.gov/42342500/", "also": [] }, { "pmid": "42342403", "title": "Effects of auricular vagal neuromodulation therapy combined with slow-paced diaphragmatic breathing in individuals with postural tachycardia syndrome: a randomised controlled trial protocol.", "journal": "BMJ open", "pub_date": "2026-06-25", "authors": "Brandl, Tobias, Pichler, Florian, Grabovac, Igor, Waldhoer, Thomas et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is a multifactorial disorder of the autonomic nervous system characterised by an excessive increase in heart rate (HR) on standing and a wide range of debilitating symptoms, including fatigue, exercise intolerance, cognitive impairment and a high prevalence of depression, anxiety and sleep disturbances. Conventional pharmacological strategies often offer limited...", "url": "https://pubmed.ncbi.nlm.nih.gov/42342403/", "also": [] }, { "pmid": "42343084", "title": "Assessing autonomic nervous system imbalance in long COVID-19 patients through heart rate variability during tilt testing.", "journal": "Scientific reports", "pub_date": "2026-06-25", "authors": "Camargo, Samuel Minucci, Dos Santos, Ana Leticia Gomes, Maximo, Stella Tassinari, da Silva et al.", "excerpt": "Long COVID-19 is recognized as a condition associated with autonomic nervous system (ANS) dysfunction. However, quantitative evidence of its impact on heart rate variability (HRV) and blood pressure (BP) regulation during postural changes remains limited.", "url": "https://pubmed.ncbi.nlm.nih.gov/42343084/", "also": [] } ], "mcas": [ { "pmid": "42365403", "title": "Role of gamma-aminobutyric acid-ergic neurons in the thalamic reticular nucleus in regulating sleep-wake cycles in mice treated with acupuncture for insomnia.", "journal": "Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan", "pub_date": "2026-06-28", "authors": "Xiaoxiao, L U, Yipeng, X U, Minjie, Zhou, Chengshun, Zhang et al.", "excerpt": "To test whether acupuncture improves sleep by enhancing gamma-aminobutyric acid-ergic (GABA) neuronal activity in the thalamic reticular nucleus (TRN). We established an animal model using p-chlorophenylalanine (PCPA).", "url": "https://pubmed.ncbi.nlm.nih.gov/42365403/", "also": [] }, { "pmid": "42360286", "title": "Protein-Free Diet Aggravates Food Allergy Response via the Consumption of Glycochenodeoxycholic Acid in a Murine Model.", "journal": "Journal of agricultural and food chemistry", "pub_date": "2026-06-27", "authors": "Shi, Qiang, Chen, Chuang, Bai, Tianliang, Zhang, Shan et al.", "excerpt": "Amino acid-based formulas (AAFs) are increasingly consumed in infants with food allergy (FA), while the effects of their long-term consumption on FA remain poorly known. This study investigated the effects of the long-term consumption of AAFs on FA by subjecting neonatal mice to an amino acid-based diet (AAD).", "url": "https://pubmed.ncbi.nlm.nih.gov/42360286/", "also": [] }, { "pmid": "42363232", "title": "Outcomes and prognostic factors in patients with systemic mastocytosis and an associated myeloid neoplasm: an international ECNM registry study.", "journal": "Journal of hematology & oncology", "pub_date": "2026-06-27", "authors": "Hermine, Olivier, Debeaupuis, Orianne, Damaj, Gandhi, Lübke, Johannes et al.", "excerpt": "Systemic mastocytosis (SM) is a spectrum of hematologic disorders characterized by accumulation of atypical mast cells (MCs) in extracutaneous organs. SM with an associated hematologic neoplasm (SM-AHN), the most frequent subtype of advanced SM, is predominantly associated with myeloid neoplasms, consistent with shared clonal architecture.", "url": "https://pubmed.ncbi.nlm.nih.gov/42363232/", "also": [] }, { "pmid": "42361439", "title": "Mast cell proteases and their significance in physiology, pathology, and therapeutic approaches.", "journal": "Pharmacological reviews", "pub_date": "2026-06-27", "authors": "Derakhshani, Afshin, Mahajan, Leela, Lesack, Kyle, Saranjam, Navid et al.", "excerpt": "Mast cells (MCs) are versatile, multifunctional immune cells with broad roles in physiological homeostasis and pathogenic processes. MCs are found in most tissues, including skin, lungs, intestines, and peritoneum, and they vary in numbers, types, and biological functions.", "url": "https://pubmed.ncbi.nlm.nih.gov/42361439/", "also": [] }, { "pmid": "42362092", "title": "Loss of epidermal miR-149 sensitizes to skin inflammation.", "journal": "The Journal of allergy and clinical immunology", "pub_date": "2026-06-27", "authors": "Luo, Longlong, Yuan, Hao, Srivastava, Ankit, Annusver, Karl et al.", "excerpt": "Keratinocytes play a central role in amplifying skin inflammation in psoriasis and atopic dermatitis (AD). However, the epithelial-intrinsic regulators involved in responsiveness to inflammatory cues remain poorly defined.", "url": "https://pubmed.ncbi.nlm.nih.gov/42362092/", "also": [] }, { "pmid": "42358594", "title": "Innovative diagnostic techniques and their clinical implications in food allergy: current clinical practice and future perspectives.", "journal": "Frontiers in allergy", "pub_date": "2026-06-26", "authors": "Rossi, Carlo Maria, Merli, Stefania, Borgonovo, Linda, Giardina, Michelle et al.", "excerpt": "Food allergy (FA) is an immune-mediated adverse reaction to food components (mainly proteins) and represents an increasing global health problem, affecting millions of individuals and imposing substantial clinical, psychosocial, and economic burdens. Accurate diagnosis is essential to prevent life-threatening reactions while avoiding unnecessary dietary restrictions and impaired quality of life.", "url": "https://pubmed.ncbi.nlm.nih.gov/42358594/", "also": [] }, { "pmid": "42349175", "title": "Benzo(a)pyrene aggregating lung inflammation via inducing IL1R1 expression in asthma: Insights from network toxicology, single-cell transcriptomics, and Mendelian randomization.", "journal": "Ecotoxicology and environmental safety", "pub_date": "2026-06-26", "authors": "Lu, Xi, Ji, Siqin, Liu, Jinyu, Sun, Yipeng et al.", "excerpt": "Exposure to benzo(a)pyrene (BaP) negatively affects lung inflammation in patients with asthma. However, there is a lack of systematic research on the key mechanisms of BaP toxicity in asthma.", "url": "https://pubmed.ncbi.nlm.nih.gov/42349175/", "also": [] }, { "pmid": "42355859", "title": "A Follow-Up Study of the Supraaortic and Intracranial Vessels, Cerebrovascular Reactivity, Brain Vascular Lesions and Atrophy in Patients with Rheumatoid Arthritis.", "journal": "Journal of clinical medicine", "pub_date": "2026-06-26", "authors": "Sas, Attila, Jónyer, Dávid, Valikovics, Attila, Kostyál, László et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42355859/", "also": [] }, { "pmid": "42345003", "title": "Treatment Approaches for Omalizumab-Refractory Chronic Spontaneous Urticaria.", "journal": "Journal of inflammation research", "pub_date": "2026-06-25", "authors": "Ensina, Luis Felipe, Ferrer, Marta, Al-Ahmad, Mona, Fomina, Daria et al.", "excerpt": "Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that impairs health-related quality of life. Although omalizumab is a cornerstone treatment for patients uncontrolled with up-dosed second-generation H1-antihistamines, some patients remain partially responsive or refractory.", "url": "https://pubmed.ncbi.nlm.nih.gov/42345003/", "also": [] }, { "pmid": "42341525", "title": "Therapeutic effects of jaceosidin on atopic dermatitis via ubiquitin-mediated JAK1 degradation.", "journal": "Phytomedicine : international journal of phytotherapy and phytopharmacology", "pub_date": "2026-06-25", "authors": "Wei, Ruoqu, Cheng, Wenjie, Zhang, Jie, Zou, Quan et al.", "excerpt": "Atopic dermatitis (AD) is a prevalent inflammatory skin disease with substantial clinical burden. Jaceosidin (JAC), a trihydroxy-dimethoxy flavone primarily isolated from Artemisia genus and several other plants, possesses potent immunomodulatory and anti-inflammatory activities with therapeutic potential for inflammatory skin diseases.", "url": "https://pubmed.ncbi.nlm.nih.gov/42341525/", "also": [] }, { "pmid": "42345616", "title": "P2 Receptors as Therapeutic Targets in Allergic Rhinitis: Insights From the Use of Natural Products and Preclinical Studies.", "journal": "Journal of immunology research", "pub_date": "2026-06-25", "authors": "Pereira, Thalita Calvet, Rocha, Leandro, Faria, Robson Xavier", "excerpt": "Allergic rhinitis (AR) is a chronic inflammatory disorder of the upper airways that is mediated by immunoglobulin E (IgE) and triggered by environmental allergens. Current pharmacological therapies, including antihistamines, corticosteroids, and immunotherapy, offer symptomatic relief but are limited by their incomplete disease-modulating effects and potential adverse side effects.", "url": "https://pubmed.ncbi.nlm.nih.gov/42345616/", "also": [] }, { "pmid": "42347019", "title": "Nasal Cytology as a Local Biomarker of Airway Inflammation: A Paradigm Shift in Precision Medicine.", "journal": "Pathophysiology : the official journal of the International Society for Pathophysiology", "pub_date": "2026-06-25", "authors": "Gelardi, Matteo", "excerpt": "Biomarker-driven approaches have markedly improved the stratification and management of airway inflammatory diseases. However, in everyday clinical practice, these strategies still rely mainly on systemic indicators, which often provide only an indirect view of the inflammatory processes occurring within the airway mucosa.", "url": "https://pubmed.ncbi.nlm.nih.gov/42347019/", "also": [] }, { "pmid": "42344483", "title": "INVA8001, a novel and highly selective chymase inhibitor, ameliorates liver inflammation, fibrosis, and hyperplasia in Mdr2 knockout mice.", "journal": "Frontiers in medicine", "pub_date": "2026-06-25", "authors": "Sharma, Sameer, Chen, Lixian, Zhou, Tianhao, Chawla, Meenakshi et al.", "excerpt": "Mast cells (MCs) play a significant role in autoimmune diseases by mediating inflammatory responses, innate and adaptive responses, angiogenesis, and various pathological processes. In chronic liver diseases, MC numbers are significantly increased, and their degranulation leads to release of mediators, including chymase, which increases inflammation, activates hepatic stellate cells (HSCs), leading to fibrosis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42344483/", "also": [] }, { "pmid": "42343635", "title": "Esculetin attenuates migraine-like pain via CGRP suppression and meningeal mast cell modulation in rat models.", "journal": "Journal of Zhejiang University. Science. B", "pub_date": "2026-06-25", "authors": "Gonul, Ayca Nur, Torun, Ibrahim Ethem, Kilinc, Yasemin Baranoglu, Kilinc, Erkan", "excerpt": "Growing evidence suggests that esculetin, a 5-lipoxygenase inhibitor, has pharmacotherapeutic potential due to its various pharmacological properties, such as potent anti-inflammatory, anti-nociceptive, and γ-aminobutyric acid type A (GABA 越来越多的证据表明，秦皮乙素作为一种5-脂氧合酶抑制剂，因其具有强效抗炎、抗伤害感受及γ-氨基丁酸A型（GABA", "url": "https://pubmed.ncbi.nlm.nih.gov/42343635/", "also": [] }, { "pmid": "42343980", "title": "Differential Regulation of Granule Release in Platelets and Immune Cells.", "journal": "TH open : companion journal to thrombosis and haemostasis", "pub_date": "2026-06-25", "authors": "Xia, Qing, Hu, Jiandao, Sun, Hongcun, Zhu, Zhixiang et al.", "excerpt": "Platelets and certain immune cells contain releasable granules that play essential roles in hemostasis and immune regulation. However, the regulatory mechanisms governing degranulation of platelets versus immune cells remain incompletely understood.", "url": "https://pubmed.ncbi.nlm.nih.gov/42343980/", "also": [] }, { "pmid": "42337945", "title": "Melittin in AllergoOncology: From Honey Bee Venom to Anti-Cancer Therapeutic Innovation-An EAACI Position Paper.", "journal": "Allergy", "pub_date": "2026-06-24", "authors": "Jimenez-Rodriguez, Teodorikez-Wilfox, Ahmetaj, Luljeta, Alfaya Arias, Teresa, Boni, Elisa et al.", "excerpt": "Honey bee venom (HBV) represents a unique interface between allergy and oncology, exemplifying how allergen-derived molecules can be repurposed as anti-cancer agents. Melittin, the principal component of HBV, accounts for 40%-50% of its dry weight and is responsible for most of its biological activity.", "url": "https://pubmed.ncbi.nlm.nih.gov/42337945/", "also": [] }, { "pmid": "42327780", "title": "The association between atopic dermatitis and rosacea: a comprehensive review from comorbidities to pathogenic mechanisms.", "journal": "Frontiers in immunology", "pub_date": "2026-06-22", "authors": "Zeng, Yuewei, Feng, Yanyan", "excerpt": "Atopic dermatitis (AD) and rosacea have traditionally been regarded as two distinct inflammatory skin disorders with divergent pathophysiology. However, emerging evidence has progressively revealed unexpected convergences between these conditions in clinical manifestations, comorbidity profiles and pathogenic mechanisms-raising the question of whether the apparent mechanistic overlaps represent true...", "url": "https://pubmed.ncbi.nlm.nih.gov/42327780/", "also": [] }, { "pmid": "42329455", "title": "Identification of circadian rhythm-associated key genes in metabolic dysfunction-associated fatty liver disease.", "journal": "Clinical and experimental medicine", "pub_date": "2026-06-22", "authors": "Luo, Jinbo, Ma, Xiuying, Wang, Quanyu, Zhang, Ruyi et al.", "excerpt": "As of now, current studies have confirmed that circadian rhythm genes (CRGs) can modulate the onset and development of metabolic dysfunction-associated fatty liver disease (MAFLD). Leveraging computational biology methodologies, systematic and thorough investigations into MAFLD and CRGs enhance our capacity to gain deeper insights into the disease's pathogenic mechanisms.", "url": "https://pubmed.ncbi.nlm.nih.gov/42329455/", "also": [] }, { "pmid": "42326011", "title": "Early life stress and the pathogenesis of visceral hypersensitivity: mechanisms and implications for disorders of gut-brain interaction.", "journal": "Frontiers in cell and developmental biology", "pub_date": "2026-06-22", "authors": "Tao, Enfu", "excerpt": "Early life stress (ELS) is a major risk factor for disorders of gut-brain interaction (DGBIs), particularly irritable bowel syndrome (IBS), through the induction of persistent visceral hypersensitivity. This review synthesizes evidence from epidemiological studies, clinical observations, and preclinical models to establish ELS-induced visceral hypersensitivity as a core pathophysiological axis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42326011/", "also": [] }, { "pmid": "42327770", "title": "Chronic spontaneous cholinergic urticaria: advances in immunological mechanisms focusing on neuro-immune crosstalk and novel targeted therapeutic strategies.", "journal": "Frontiers in immunology", "pub_date": "2026-06-22", "authors": "Yang, Meilv, Lin, Suxian, Lu, Yang, Jin, Huanzhi et al.", "excerpt": "Chronic spontaneous cholinergic urticaria (CSU-Chol) is a chronic inflammatory skin disorder characterized by intense pruritus and small wheals triggered by a rise in core body temperature. This review aims to systematically elucidate its complex pathogenesis, with a particular focus on the pivotal role of neuro-immune crosstalk in disease initiation and progression.", "url": "https://pubmed.ncbi.nlm.nih.gov/42327770/", "also": [] } ], "other-post-viral": [ { "pmid": "42335646", "title": "Immune metabolic remodeling during exercise rehabilitation: Linking skeletal muscle regeneration, bone homeostasis, and systemic immune adaptation.", "journal": "Tissue & cell", "pub_date": "2026-06-24", "authors": "Wang, Fei, Qin, Wenjie", "excerpt": "Exercise rehabilitation harnesses immune metabolic remodeling to drive coordinated skeletal muscle regeneration, bone homeostasis, and systemic immune adaptation. Physical activity functions as a controlled metabolic stressor that reprograms immune cell metabolism-shifting macrophages from glycolytic M1 to oxidative M2 phenotypes, expanding regulatory T cells through fatty acid oxidation and ketone body signaling...", "url": "https://pubmed.ncbi.nlm.nih.gov/42335646/", "also": [] } ] }, "trials": [ { "nct_id": "NCT07388550", "title": "Phase I Open-Label Safety Trial of Pembrolizumab for Neurological Post- Acute Sequelae of SARS-CoV-2 (PD1-PASC I)", "status": "NOT_YET_RECRUITING", "phase": "PHASE1", "last_updated": "2026-06-26", "start_date": "2026-07-01", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Keytruda" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07388550" }, { "nct_id": "NCT05874037", "title": "Fluvoxamine for Long COVID-19", "status": "COMPLETED", "phase": "PHASE2", "last_updated": "2026-06-25", "start_date": "2023-05-15", "sponsor": "Washington University School of Medicine", "sponsor_type": "OTHER", "agents": [ "Fluvoxamine" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05874037" }, { "nct_id": "NCT07546539", "title": "Photobiomodulation in Chronic Fatigue Syndrome", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-06-24", "start_date": "2026-06-15", "sponsor": "University of Lahore", "sponsor_type": "OTHER", "agents": [ "Photobiomodulation" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07546539" }, { "nct_id": "NCT04827992", "title": "Evaluation of Medical Cannabis and Prescription Opioid Taper Support for Reduction of Pain and Opioid Dose in Patients With Chronic Non-Cancer Pain", "status": "COMPLETED", "phase": "NA", "last_updated": "2026-06-24", "start_date": "2021-08-23", "sponsor": "Massachusetts General Hospital", "sponsor_type": "OTHER", "agents": [ "Cannabis", "Prescription Opioid Taper Support" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT04827992" }, { "nct_id": "NCT05977179", "title": "Dietary Intervention to Mitigate Post-Acute COVID-19 Syndrome", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-06-23", "start_date": "2025-05-12", "sponsor": "University of Maryland, Baltimore", "sponsor_type": "OTHER", "agents": [ "Dietary Intervention To Mitigate Post-Acute Covid-19 Syndrome" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT05977179" }, { "nct_id": "NCT07661862", "title": "PERCEIVE-Outreach: A Scalable, Risk-Based Model for Managing Persistent Cardiovascular Impact in Long COVID", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-06-22", "start_date": "2026-04-01", "sponsor": "University of Tasmania", "sponsor_type": "OTHER", "agents": [ "Perceive-Outreach Intervention" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07661862" }, { "nct_id": "NCT07655375", "title": "Study Evaluating the Effect of UCB8600 on Mast Cell Activation in the Human Gut", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-06-22", "start_date": "2026-06", "sponsor": "Guy Boeckxstaens", "sponsor_type": "OTHER", "agents": [ "Sample Collection" ], "conditions": [ "mcas", "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07655375" }, { "nct_id": "NCT06231238", "title": "Balance Acceptance and Commitment Therapy for Long COVID", "status": "ACTIVE_NOT_RECRUITING", "phase": "NA", "last_updated": "2026-06-22", "start_date": "2024-06-04", "sponsor": "King's College London", "sponsor_type": "OTHER", "agents": [ "Balance Acceptance And Commitment Therapy" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06231238" }, { "nct_id": "NCT04542161", "title": "Assessment of N-Acetylcysteine as Therapy for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome", "status": "ACTIVE_NOT_RECRUITING", "phase": "PHASE2", "last_updated": "2026-06-22", "start_date": "2020-09-01", "sponsor": "Weill Medical College of Cornell University", "sponsor_type": "OTHER", "agents": [ "N-Acetylcysteine (NAC)" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT04542161" } ], "feed_latest_pub_date": "2026-07-10", "numbers": { "studies_tracked": 544, "trials_tracked": 620, "biomarkers_catalogued": 546, "feeds": 8 }, "feed_updates": { "long-covid": "2026-07-07", "me-cfs": "2026-07-06", "pacvs": "2026-06-25", "lyme": "2026-07-08", "gulf-war-illness": "2026-07-09", "pots": "2026-07-10", "mcas": "2026-07-10", 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