{ "id": "2026-W24", "year": 2026, "week": 24, "week_monday": "2026-06-08", "week_sunday": "2026-06-14", "asof": "2026-06-14", "window_start": "2026-06-08", "window_end": "2026-06-14", "window_days": 7, "widened": false, "strict_study_count": 25, "strict_trial_count": 7, "study_count": 25, "trial_count": 7, "studies": { "long-covid": [], "me-cfs": [ { "pmid": "42284918", "title": "UHPLC-Q-Exactive Orbitrap MS-based brain-gut metabolomics implicates multi-pathway modulation by Ginseng stem-leaf saponins in chronic fatigue syndrome mice.", "journal": "Journal of pharmaceutical and biomedical analysis", "pub_date": "2026-06-13", "authors": "Wu, Wei, Aishan, Saibire, Zhang, Meng, Chen, Xue et al.", "excerpt": "Ginseng stem-leaf saponins (GSLS) were evaluated as potential bioactive food ingredients by characterizing brain-gut metabolic disturbances in a chronic fatigue syndrome (CFS) mouse model and assessing the regulatory effects of GSLS using ultra-high-performance liquid chromatography-Q-Exactive Orbitrap mass spectrometry (UHPLC-Q-Exactive Orbitrap MS). Male C57BL/6 mice were assigned to control, model, positive...", "url": "https://pubmed.ncbi.nlm.nih.gov/42284918/", "also": [] }, { "pmid": "42286686", "title": "Two-timepoint multidomain follow-up of post-COVID condition and ME/CFS: overlapping autonomic, small-fiber, and cognitive changes.", "journal": "Journal of translational medicine", "pub_date": "2026-06-13", "authors": "Azcue, N, Barranco, C, Tijero-Merino, B, Acera, M et al.", "excerpt": "Post-COVID condition (PCC) and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) show marked clinical overlap, suggesting a shared post-infectious pathophysiology. This study aims to characterize the longitudinal change of autonomic function, small-fiber integrity, cognitive performance, and clinical symptoms in PCC and ME/CFS, and to determine whether trajectories differ between diagnostic groups.", "url": "https://pubmed.ncbi.nlm.nih.gov/42286686/", "also": [] }, { "pmid": "42286685", "title": "Combatting ventilator induced diaphragm dysfunction with human bone marrow mesenchymal stromal cell-derived extracellular vesicles.", "journal": "Skeletal muscle", "pub_date": "2026-06-13", "authors": "Wen, Ya, Zhang, Xiang, Hedström, Yvette, Cacciani, Nicola et al.", "excerpt": "Prolonged mechanical ventilation is closely associated with ventilator-induced lung injury (VILI) and ventilator-induced diaphragm dysfunction (VIDD). These two conditions occur in parallel and contribute to delayed weaning, prolonged intensive care unit (ICU) stay, and poor clinical outcomes.", "url": "https://pubmed.ncbi.nlm.nih.gov/42286685/", "also": [] }, { "pmid": "42277526", "title": "[Pain in post-acute infection syndromes: clinical classification and practical management].", "journal": "MMW Fortschritte der Medizin", "pub_date": "2026-06-12", "authors": "Luchting, Benjamin", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42277526/", "also": [] }, { "pmid": "42279648", "title": "The Potential Role of Camel Milk in Alleviating Chronic Fatigue Syndrome in Mice: A Network Pharmacology and In Vivo Validation Study.", "journal": "Foods (Basel, Switzerland)", "pub_date": "2026-06-12", "authors": "Li, Hongman, Osman, Henigul, Zhang, Hongyan, Chen, He et al.", "excerpt": "Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a complex and debilitating disorder with limited treatment options. Camel milk (CM), known for its rich nutrients and anti-fatigue properties, may offer multi-target benefits for managing this condition.", "url": "https://pubmed.ncbi.nlm.nih.gov/42279648/", "also": [] }, { "pmid": "42277311", "title": "Significant aggravation of pre-existing myalgic encephalomyelitis/chronic fatigue syndrome following proton beam therapy for sphenoid wing meningioma: case report.", "journal": "Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]", "pub_date": "2026-06-12", "authors": "Fischer, Christian, Seidlitz, Annekatrin, Krause, Mechthild", "excerpt": "Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating multisystem disorder characterized by profound fatigue, post-exertional malaise (PEM), immune dysregulation, and mitochondrial dysfunction. While radiation exposure has been linked to fatigue syndromes with overlapping pathophysiology, no previous reports have described the effects of therapeutic radiation, including proton beam...", "url": "https://pubmed.ncbi.nlm.nih.gov/42277311/", "also": [] }, { "pmid": "42278463", "title": "Raman Spectroscopy Combined with Machine Learning Reveals Myalgic Encephalomyelitis-Associated Biomolecular Signatures at Rest and After Standardized Stress.", "journal": "International journal of molecular sciences", "pub_date": "2026-06-12", "authors": "Heidarifard, Maryam, Moezzi, Atefeh, Dallaire, Frédérick, Ember, Katherine et al.", "excerpt": "Myalgic encephalomyelitis (ME) is characterized by profound fatigue, post-exertional malaise (PEM), and cognitive dysfunction. Despite its clinical significance, the pathophysiology of PEM and disease heterogeneity remain unclear, and no validated biomarkers are available for rapid diagnosis or monitoring.", "url": "https://pubmed.ncbi.nlm.nih.gov/42278463/", "also": [] }, { "pmid": "42278300", "title": "Irisin Signaling Resistance in Myalgic Encephalomyelitis: A Proposed Mechanistic Framework for Post-Exertional Malaise Involving the TSP-1-HSP90α-αvβ5 Axis.", "journal": "International journal of molecular sciences", "pub_date": "2026-06-12", "authors": "Souma, Bernard, Elremaly, Wesam, Akoume, Marie-Yvonne, Elbakry, Mohamed et al.", "excerpt": "Myalgic Encephalomyelitis (ME) is a chronic, multisystem disease characterized by systemic metabolic dysfunction and post-exertional malaise (PEM). In this study, we investigated the dysregulation of irisin, an exercise-induced myokine, and its potential antagonism by thrombospondin-1 (TSP-1).", "url": "https://pubmed.ncbi.nlm.nih.gov/42278300/", "also": [] }, { "pmid": "42276999", "title": "Benchmarking large language models for cell-free RNA diagnostic biomarker discovery.", "journal": "Nature communications", "pub_date": "2026-06-12", "authors": "Gaudio, Hunter A, Bliss, Andrew, Loy, Conor J, Eweis-LaBolle, Daniel et al.", "excerpt": "Large language models can synthesize biomedical knowledge, parse vast amounts of data, and generate code, positioning them as promising tools for biomarker discovery from high-throughput omics data. Here, we benchmark six models from OpenAI, Anthropic, and Google on plasma cell-free RNA datasets spanning three clinical cohorts: Kawasaki disease versus multisystem inflammatory syndrome in children, active...", "url": "https://pubmed.ncbi.nlm.nih.gov/42276999/", "also": [] }, { "pmid": "42274123", "title": "Dynamic microclot profiling: thromboelastography advances precision management in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.", "journal": "Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis", "pub_date": "2026-06-11", "authors": "Saleem, Shafaq, Hussain, Ahmad, Haroon, Muhammad, Raza, Ahmad et al.", "excerpt": "Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) share overlapping symptoms, and emerging evidence implicates persistent fibrinoid microclots in their pathophysiology, contributing to impaired microcirculation. This review explores the role of microclots and evaluates thromboelastography (TEG) as a potential diagnostic tool.", "url": "https://pubmed.ncbi.nlm.nih.gov/42274123/", "also": [] }, { "pmid": "42261335", "title": "A new patient-led approach to building research infrastructure and evidence generation.", "journal": "Oxford open immunology", "pub_date": "2026-06-09", "authors": "Cousins, Oonagh, Leeming, Harry, Putrino, David, Gordon, Janna", "excerpt": "Over recent decades, patient and public involvement (PPI) has become a more established element of health research policy, although its implementation is often criticized for tokenism and for underrepresenting marginalized groups. In fields such as complex chronic illness (CCI), where formal research activity has historically been limited, conventional PPI frameworks have had little scope for meaningful application.", "url": "https://pubmed.ncbi.nlm.nih.gov/42261335/", "also": [] } ], "pacvs": [ { "pmid": "42281871", "title": "Clinical predictors of SARS-CoV-2 vaccine immunogenicity in kidney transplant recipients at a rural center.", "journal": "World journal of transplantation", "pub_date": "2026-06-12", "authors": "Basuli, Debargha, Ross, Bonnie, Rebellato, Lorita M", "excerpt": "Kidney transplant recipients (KTR) have impaired immune responses to vaccination and remain at increased risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection despite mRNA coronavirus disease 2019 (COVID-19) vaccination. Data from rural and medically underserved transplant populations remain limited.", "url": "https://pubmed.ncbi.nlm.nih.gov/42281871/", "also": [] }, { "pmid": "42283396", "title": "Acute and chronic kidney injury following COVID-19 infection and vaccination: a narrative review.", "journal": "European journal of translational myology", "pub_date": "2026-06-12", "authors": "Saadat, Seyed Hassan, Javanbakht, Mohammad, Amini, Hossein, Rouhollahei, Mahboubeh et al.", "excerpt": "This narrative review examines acute and chronic kidney injury following COVID-19 infection and vaccination, discussing the mechanism of SARS-CoV-2 entry into host cells through the ACE2 receptor - highly expressed in renal tissues - facilitating the viral invasion. Viral RNA has been detected in the urine of patients infected with SARS-CoV-2, suggesting direct renal involvement.", "url": "https://pubmed.ncbi.nlm.nih.gov/42283396/", "also": [] } ], "lyme": [ { "pmid": "42265463", "title": "Risk factors for EBV reactivation and impact of graft composition following GVHD prophylaxis with rabbit ATG or PTCy.", "journal": "Bone marrow transplantation", "pub_date": "2026-06-10", "authors": "Thiant, Stéphanie, Dufresne, Simon, Ahmad, Imran, Cohen, Sandra et al.", "excerpt": "EBV reactivation is frequent after allogeneic HCT and can lead to post-transplant lymphoproliferative disorder (PTLD). While ATG and PTCy are established strategies to prevent GVHD, their comparative impact on EBV reactivation remains insufficiently characterized.", "url": "https://pubmed.ncbi.nlm.nih.gov/42265463/", "also": [] } ], "gulf-war-illness": [ { "pmid": "42277823", "title": "Observational and genetically-informed characterization of Gulf War Illness symptoms in 1990-1991 Gulf War deployed Veterans and non-deployed Gulf War Era Veterans.", "journal": "Environmental health : a global access science source", "pub_date": "2026-06-12", "authors": "He, Jun, Pathak, Gita A, Cabrera-Mendoza, Brenda, Qiu, Dan et al.", "excerpt": "Gulf War Illness (GWI) has been identified in more than 20% of Veterans following military service in the 1990-1991 Gulf War (GW). Unfortunately, after several decades, GWI pathogenesis remains unclear and the patterns of GWI symptom co-occurrence are still poorly understood.", "url": "https://pubmed.ncbi.nlm.nih.gov/42277823/", "also": [] } ], "pots": [ { "pmid": "42285365", "title": "Dysautonomia and joint hypermobility reflect a distinct subtype in eosinophilic esophagitis.", "journal": "The Journal of allergy and clinical immunology", "pub_date": "2026-06-13", "authors": "Patel, Ritam H, Peraza, Jose Roberto, Keeley, Kaitlin, Dehghani, Zeinab et al.", "excerpt": "Joint hypermobility (JH) and autonomic symptoms commonly coexist and are associated with gastrointestinal symptoms and poor quality of life. Gastric and duodenal mast cells (MCs) may be increased in these patients; however, their relevance to eosinophilic esophagitis (EoE) is unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42285365/", "also": [] }, { "pmid": "42279051", "title": "Clinical and Immunovirological Characteristics Associated with Cardiovascular Dysautonomia in Long COVID.", "journal": "Journal of clinical medicine", "pub_date": "2026-06-12", "authors": "Renaudineau, Yves, Teillaud, Selena, Chaves, Sébastien De Almeida, Alvarez, Muriel et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42279051/", "also": [] }, { "pmid": "42270000", "title": "Trends in antidepressant and antianxiety medication use in patients evaluated for postural orthostatic tachycardia syndrome.", "journal": "Heart rhythm", "pub_date": "2026-06-11", "authors": "Shrestha, Yash, de Souza, Russell J, Rabbi, Fazle, Mian, Owais et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42270000/", "also": [] }, { "pmid": "42275267", "title": "No association of complex regional pain syndrome and other neurological disorders with human papillomavirus vaccination in a large-scale real-world database.", "journal": "Neuroepidemiology", "pub_date": "2026-06-11", "authors": "Kitano, Taito, Yoshida, Sayaka", "excerpt": "Establishing evidence of vaccine safety is critical for optimizing vaccine coverage. This study aimed to assess the risk of developing neurological disorders following human papillomavirus (HPV) vaccination.", "url": "https://pubmed.ncbi.nlm.nih.gov/42275267/", "also": [] }, { "pmid": "42273028", "title": "Maximizing treatment response in patients with neuropathic-subtype postural orthostatic tachycardia syndrome.", "journal": "Frontiers in neurology", "pub_date": "2026-06-11", "authors": "Rilinger, Ryan G, Chin, Adeline Y, Cantrell, Christopher, Levine, Mackaleigh et al.", "excerpt": "Postural Orthostatic Tachycardia Syndrome (POTS) is notoriously difficult to diagnose and successfully treat. POTS encompasses several different subtypes, but little research attention has focused on optimizing the diagnosis and treatment of specific subtypes.", "url": "https://pubmed.ncbi.nlm.nih.gov/42273028/", "also": [] }, { "pmid": "42257809", "title": "Treatment of Headache in Children and Adolescents with POTS.", "journal": "Current pain and headache reports", "pub_date": "2026-06-08", "authors": "Nayak, Katrina, Rahman, Shaoon, Oakley, Christopher", "excerpt": "This review provides an overview of POTS in children and adolescents with headaches, with a focus on the pharmacologic and non-pharmacologic treatment approaches. Current research in headache and POTS focuses on an individualized management that includes a multi-tiered patient-centric approach that selects treatments to match specific phenotypes.", "url": "https://pubmed.ncbi.nlm.nih.gov/42257809/", "also": [] }, { "pmid": "42254140", "title": "Diet and environment: unexplored influences on sleep quality in postural orthostatic tachycardia syndrome (POTS).", "journal": "Annals of medicine and surgery (2012)", "pub_date": "2026-06-08", "authors": "Fatima, Syeda Samia, Ayaz, Syeda Nashrah, Raza, Ahmed Asad, Samadi, Abedin", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) is a chronic autonomic disorder characterized by an excessive increase in heart rate upon standing, accompanied by symptoms such as dizziness, fatigue, palpitations, cognitive impairment, and sleep disturbances. Sleep dysfunction is increasingly recognized as a significant contributor to symptom burden and reduced quality of life among individuals with POTS.", "url": "https://pubmed.ncbi.nlm.nih.gov/42254140/", "also": [] } ], "mcas": [], "other-post-viral": [ { "pmid": "42278343", "title": "Fibromyalgia: A Multifactorial Pain Disorder.", "journal": "International journal of molecular sciences", "pub_date": "2026-06-12", "authors": "Aoe, Tomohiko", "excerpt": "Fibromyalgia represents a complex chronic pain condition in which patients experience widespread pain accompanied by fatigue and a broad range of physical and psychological symptoms. Diagnosis relies on symptom-based diagnostic criteria that lack objectivity, making it difficult to properly diagnose and treat.", "url": "https://pubmed.ncbi.nlm.nih.gov/42278343/", "also": [] }, { "pmid": "42260029", "title": "Health-related quality of life changes in patients with Q-fever fatigue syndrome: a four-year follow-up study, 10 years post-infection.", "journal": "Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation", "pub_date": "2026-06-09", "authors": "Stemerdink, N C, Heemskerk, S C M, Hartman, E, Wesseling, M et al.", "excerpt": "Q-fever can cause long-term health complications such as Q-fever Fatigue Syndrome (QFS), which may severely impact patients' Health-Related Quality of Life (HRQoL). This study investigated change of HRQoL in QFS patients over time, and explored predictors associated with change using longitudinal data.", "url": "https://pubmed.ncbi.nlm.nih.gov/42260029/", "also": [] }, { "pmid": "42258389", "title": "Psychiatric and behavioral symptoms after pediatric herpes simplex virus type 1 encephalitis: An exploratory case series.", "journal": "Bulletin of the Menninger Clinic", "pub_date": "2026-06-08", "authors": "Galland, Patrick, Fischer, Frank, Steven, Berenike, Seifert, Johanna et al.", "excerpt": "To exploratively describe long-term psychiatric and behavioral symptoms in pediatric survivors of herpes simplex virus type 1 encephalitis. In this retrospective descriptive case series conducted at two tertiary pediatric centers, admissions from 2000 to 2022 were screened for confirmed herpes simplex virus type 1 encephalitis.", "url": "https://pubmed.ncbi.nlm.nih.gov/42258389/", "also": [] } ] }, "trials": [ { "nct_id": "NCT05350774", "title": "Immunotherapy for Neurological Post-Acute Sequelae of SARS-CoV-2", "status": "ENROLLING_BY_INVITATION", "phase": "PHASE2", "last_updated": "2026-06-12", "start_date": "2023-07-10", "sponsor": "National Institute of Neurological Disorders and Stroke (NINDS)", "sponsor_type": "NIH", "agents": [ "Iv Normal Saline", "Iv Immunoglobulin" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT05350774" }, { "nct_id": "NCT05947136", "title": "PASCA-MM Study. Impact of the PASCA (PArcours de Santé au Cours du CAncer) Program on Complications Associated With Multiple Myeloma and/or Its Treatments in the Context of a First Hematopoietic Stem Cell Autograft, in Adults Aged 18 to 70.", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-06-11", "start_date": "2024-01-19", "sponsor": "Centre Leon Berard", "sponsor_type": "OTHER", "agents": [ "Interpretation Of The Results From The Detection Visit", "Explaining Detection Results And Referrals To The Patient", "Early Medical Care Through The Network" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT05947136" }, { "nct_id": "NCT07359482", "title": "sElective Serotonin reuPtake inhibitoRs In posT-covid After COVID-19", "status": "RECRUITING", "phase": "PHASE3", "last_updated": "2026-06-09", "start_date": "2026-06-04", "sponsor": "Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)", "sponsor_type": "OTHER", "agents": [ "Fluvoxamine" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07359482" }, { "nct_id": "NCT05618067", "title": "The Impact of Improved Vagal Function on Periaqueductal Gray Connectivity", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-06-09", "start_date": "2026-07", "sponsor": "Virginia Commonwealth University", "sponsor_type": "OTHER", "agents": [ "Breathing Exercise Training" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT05618067" }, { "nct_id": "NCT07523113", "title": "ME/CFS Brain Fog: Cognitive Rehabilitation Trial", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-06-08", "start_date": "2026-06", "sponsor": "University of Alabama at Birmingham", "sponsor_type": "OTHER", "agents": [ "Processing Speed Training", "In-Session Instrumental Activities Of Daily Living Training", "Transfer Package", "Follow Up Phone Calls", "Trans-Auricular Vagus Nerve Stimulation: High Intensity", "In-Session Brain Health Training", "Reaction Time Training", "Trans-Auricular Vagus Nerve Stimulation: Low Intensity" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07523113" }, { "nct_id": "NCT07491315", "title": "Is Post-exertional Symptom Exacerbation Specific to Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome? A Study Comparing Patients With Myalgic Encephalomyelitis / Chronic Fatigue Syndrome and Patients With Cardiac Diseases Who Underwent an Exercise Test.", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-06-08", "start_date": "2025-06-24", "sponsor": "Hôpital Européen Marseille", "sponsor_type": "OTHER", "agents": [ "Exercise Test On Ergocycle", "Near Infrared Spectroscopy" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07491315" }, { "nct_id": "NCT07468604", "title": "Cervicothoracic Sympathetic Block Evaluation for Post COVID Condition", "status": "RECRUITING", "phase": "PHASE4", "last_updated": "2026-06-08", "start_date": "2026-05-19", "sponsor": "University Health Network, Toronto", "sponsor_type": "OTHER", "agents": [ "5 Ml Of 0.25% Bupivacaine With Epinephrine" ], "conditions": [ "other-post-viral" ], "mapped_conditions": [ "Unspecified / Overlap" ], "link": "https://clinicaltrials.gov/study/NCT07468604" } ], "feed_latest_pub_date": "2026-07-10", "numbers": { "studies_tracked": 544, "trials_tracked": 620, "biomarkers_catalogued": 546, "feeds": 8 }, "feed_updates": { "long-covid": "2026-07-07", "me-cfs": "2026-07-06", "pacvs": "2026-06-25", "lyme": "2026-07-08", "gulf-war-illness": "2026-07-09", "pots": "2026-07-10", "mcas": "2026-07-10", "other-post-viral": "2026-06-25" }, "trials_last_run": "2026-06-26", "generated_at": "2026-10-07T22:29:14+00:00" }