{ "id": "2026-W23", "year": 2026, "week": 23, "week_monday": "2026-06-01", "week_sunday": "2026-06-07", "asof": "2026-06-07", "window_start": "2026-06-01", "window_end": "2026-06-07", "window_days": 7, "widened": false, "strict_study_count": 21, "strict_trial_count": 10, "study_count": 21, "trial_count": 10, "studies": { "long-covid": [], "me-cfs": [ { "pmid": "42249231", "title": "Novel activity and participation scales for children, adolescents, and young adults with postacute infection and vaccination syndromes and/or ME/CFS.", "journal": "European journal of pediatrics", "pub_date": "2026-06-06", "authors": "Weidmann, Carola, Grabbe, Annika, Eberhartinger, Maria, Kircher, Alissa et al.", "excerpt": "Children, adolescents, and young adults (CYP) with postacute infection and vaccination syndromes (PAIVS), and/or myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), experience profound loss in activity and participation. We introduce and psychometrically validate two new brief, age-adapted, and domain-specific questionnaires for clinical use assessing activity and participation in this vulnerable patient...", "url": "https://pubmed.ncbi.nlm.nih.gov/42249231/", "also": [] }, { "pmid": "42249466", "title": "Hyperbaric oxygen therapy improves clinical symptoms and functional capacity and modulates thalamic connectivity in ME/CFS: a prospective cohort study.", "journal": "Journal of translational medicine", "pub_date": "2026-06-06", "authors": "Kim, Laura, Cammà, Guido, Peters, Claudia Kedor, Mantwill, Maron et al.", "excerpt": "Hyperbaric oxygen therapy (HBOT) has been proposed as a treatment for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), but evidence remains limited. This study evaluated its clinical effectiveness and feasibility, as well as associated functional brain changes.", "url": "https://pubmed.ncbi.nlm.nih.gov/42249466/", "also": [] }, { "pmid": "42239825", "title": "The expanding potential of low-dose naltrexone in clinical practice with a focus on long COVID.", "journal": "The mental health clinician", "pub_date": "2026-06-04", "authors": "Pucci, Sara L, Veide, Allison, Pierce, Haley, Kaminski, Dana", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42239825/", "also": [] }, { "pmid": "42227214", "title": "Correction to \"Evidence of White Matter Neuroinflammation in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Diffusion-Based Neuroinflammation Imaging Study\".", "journal": "Human brain mapping", "pub_date": "2026-06-02", "authors": "Authors not listed", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42227214/", "also": [] }, { "pmid": "42223876", "title": "[Transdisciplinary Expert Statement: care guide for people severely affected by ME/CFS in home-based care].", "journal": "Wiener medizinische Wochenschrift (1946)", "pub_date": "2026-06-01", "authors": "Hermisson, Joachim, Schreiner, Claudia, Weichselbaumer, Stefanie, Werner, Marlene et al.", "excerpt": "Many of those affected by myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have significant care needs. However, post-exertional malaise, the defining feature of ME/CFS, means that even minor physical, orthostatic, cognitive, or sensory stressors can trigger a disproportionate worsening of health status, condition and symptoms.", "url": "https://pubmed.ncbi.nlm.nih.gov/42223876/", "also": [] }, { "pmid": "42222634", "title": "Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Leading to Assisted Suicide in a Patient in Her Late 30s: A Case Report.", "journal": "Cureus", "pub_date": "2026-06-01", "authors": "Opala, Dominika, Villiger, Erich, Levenfus, Ian", "excerpt": "A patient in her late 30s developed severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) following an Epstein-Barr virus infection. No distinct autoimmune or autoinflammatory disorder could be identified as the underlying cause of her symptoms, as the observed constellation of cytokine elevations (IL-2, IL-6, and IFN-γ) was not consistent with any known or established disease entity.", "url": "https://pubmed.ncbi.nlm.nih.gov/42222634/", "also": [] }, { "pmid": "42220511", "title": "Immune remodeling and metabolic reprogramming in chronic fatigue: insights into GPCR signaling and epigenetic regulation.", "journal": "Frontiers in immunology", "pub_date": "2026-06-01", "authors": "Hu, Zekai, Wang, Jinyan, Ma, Sicong, Zhuang, Jie et al.", "excerpt": "Inflammation-driven fatigue is a clinically significant feature of several chronic inflammatory conditions, including myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), post-COVID condition, autoimmune disease, and cancer-related fatigue. Across these conditions, partially overlapping disturbances in immune regulation, cellular metabolism, and neuroimmune signaling may contribute to persistent fatigue...", "url": "https://pubmed.ncbi.nlm.nih.gov/42220511/", "also": [] }, { "pmid": "42219745", "title": "Components and Delivery Formats of Cognitive Behavioral Therapy for Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: A Systematic Review and Component Network Meta-Analysis.", "journal": "Brain and behavior", "pub_date": "2026-06-01", "authors": "Wang, Shoujian, Ren, Jun, Fang, Sitong, Hao, Qiukui et al.", "excerpt": "Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating condition characterized by persistent fatigue, impaired functioning, and substantial societal burden. Although cognitive behavioral therapy (CBT) is commonly used for CFS/ME, the effective components and delivery formats remain unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42219745/", "also": [] } ], "pacvs": [ { "pmid": "42246405", "title": "A narrative review of COVID-19 epidemiology and mRNA vaccine impact in children <12 years during the omicron era (November 2021 - December 2025).", "journal": "Expert review of vaccines", "pub_date": "2026-06-05", "authors": "Zheng, Zhe, Yousefi, Mitra, Marks, Morgan, Dixit, Avika et al.", "excerpt": "COVID-19 continues to pose a burden in children under 12 years of age during the Omicron era (November 2021 - December 2025). Following Omicron's emergence, SARS-CoV-2 seroprevalence increased rapidly, with most children infected by ages 2-4 years.", "url": "https://pubmed.ncbi.nlm.nih.gov/42246405/", "also": [] } ], "lyme": [], "gulf-war-illness": [ { "pmid": "42222193", "title": "Mitochondrial Bioenergetic Approach to Restore Veteran Vitality: A Feasibility Pilot.", "journal": "Integrative medicine (Encinitas, Calif.)", "pub_date": "2026-06-01", "authors": "Osinubi, Omowunmi, Greer, Steven, McManus, Pauline, Carlson, Carrie J et al.", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42222193/", "also": [] } ], "pots": [ { "pmid": "42248496", "title": "What are we treating? The need for broader provider understanding of POTS, its nature, and care.", "journal": "The American journal of medicine", "pub_date": "2026-06-06", "authors": "Reyes, Jorge L, Fedorowski, Artur, Deering, Thomas, Grubb, Blair et al.", "excerpt": "Postural orthostatic tachycardia syndrome (POTS) as conventionally defined is a chronic condition (typically > 3 months duration) incorporating reproducible symptoms of orthostatic intolerance (including dizziness/lightheadedness, and near-syncope) in the absence of orthostatic hypotension (ie, absence of a sustained systolic blood pressure drop > 20mmHg with upright posture). More recently, however, the :landscape...", "url": "https://pubmed.ncbi.nlm.nih.gov/42248496/", "also": [] }, { "pmid": "42247198", "title": "Postural tachycardia during active standing: diagnostic criteria in adolescents.", "journal": "Clinical autonomic research : official journal of the Clinical Autonomic Research Society", "pub_date": "2026-06-05", "authors": "Jarjour, Imad T, Aras, Sukru, Jarjour, Laila K", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42247198/", "also": [] }, { "pmid": "42241931", "title": "Patient-reported perspectives of a temporal relationship between autonomic dysfunction and mental health symptoms in a pediatric population.", "journal": "Autonomic neuroscience : basic & clinical", "pub_date": "2026-06-05", "authors": "Frye, William S, Ward, Sydney R, Johnston, Julia D", "excerpt": "Autonomic dysfunction, characterized by orthostatic intolerance and presyncope, is understudied in youth. Mental health comorbidities are commonly reported and sometimes blamed for the onset of autonomic dysfunction; however, no studies have yet examined this relationship.", "url": "https://pubmed.ncbi.nlm.nih.gov/42241931/", "also": [] }, { "pmid": "42245008", "title": "Monocyte Oxidative Stress Underlies Persistent Immune Activation in Long COVID Postural Orthostatic Tachycardia Syndrome.", "journal": "medRxiv : the preprint server for health sciences", "pub_date": "2026-06-05", "authors": "Abd-Eldayem, Marwa A, Vinayagam, Meenakshi, Vance, Yuliya A, Paranjape, Sachin Y et al.", "excerpt": "Long COVID Postural Orthostatic Tachycardia Syndrome (LCPOTS) is characterized by persistent orthostatic tachycardia and systemic symptoms following SARS-CoV-2 infection. Many features of LCPOTS suggest ongoing immune activation, but the mechanisms driving this response remain unclear.", "url": "https://pubmed.ncbi.nlm.nih.gov/42245008/", "also": [] }, { "pmid": "42246770", "title": "Integrating psychological care into atrial fibrillation management: insights from HOPE-AF.", "journal": "European journal of cardiovascular nursing", "pub_date": "2026-06-05", "authors": "Wilson, Gemma, Tully, Phillip J, Gallagher, Celine", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42246770/", "also": [] }, { "pmid": "42235469", "title": "To tilt or not? Role of the active stand test in the evaluation of postural orthostatic tachycardia syndrome (POTS).", "journal": "Autonomic neuroscience : basic & clinical", "pub_date": "2026-06-04", "authors": "Uppal, Jaiden, Sheldon, Robert S, Raj, Satish R", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42235469/", "also": [] }, { "pmid": "42229474", "title": "Comorbidities in Ehlers-Danlos syndromes and hypermobile spectrum disorders.", "journal": "Acta ortopedica mexicana", "pub_date": "2026-06-03", "authors": "Wang, T J, Serrano-Ardila, A M", "excerpt": "hypermobile spectrum disorders (HSD) and Ehlers-Danlos syndromes (EDS) are connective tissue disorders often associated with systemic manifestations such as mast cell activation syndrome (MCAS), postural orthostatic tachycardia syndrome (POTS), irritable bowel syndrome (IBS), and autoimmune conditions, including spondyloarthritis (SpA). The overlap of these conditions complicates diagnosis and treatment.", "url": "https://pubmed.ncbi.nlm.nih.gov/42229474/", "also": [] }, { "pmid": "42222895", "title": "The long and winding road of postural orthostatic tachycardia syndrome.", "journal": "Journal of internal medicine", "pub_date": "2026-06-01", "authors": "Fedorowski, Artur", "excerpt": "No abstract available.", "url": "https://pubmed.ncbi.nlm.nih.gov/42222895/", "also": [] }, { "pmid": "42219912", "title": "Research progress on the prediction of heart rate and blood pressure in the diagnosis and prognosis of pediatric postural orthostatic tachycardia syndrome.", "journal": "Cardiology in the young", "pub_date": "2026-06-01", "authors": "Wang, Shuo, Zou, Runmei, Cai, Hong, Wang, Cheng", "excerpt": "Pediatric postural orthostatic tachycardia syndrome is one of the main haemodynamic types of neurally mediated syncope and is commonly seen in school-aged children. Heart rate and blood pressure are important physiological indicators in the human cardiovascular system.", "url": "https://pubmed.ncbi.nlm.nih.gov/42219912/", "also": [] } ], "mcas": [], "other-post-viral": [ { "pmid": "42243711", "title": "Human parvovirus B19-associated Guillain-Barré syndrome diagnosed by cerebrospinal fluid targeted next-generation sequencing: a case report and literature review.", "journal": "BMC infectious diseases", "pub_date": "2026-06-05", "authors": "Wu, Yujun, Liu, Ye, Gu, Liyan, Zhang, Yongqiu et al.", "excerpt": "Guillain-Barré syndrome (GBS) is a post-infectious autoimmune disorder of the peripheral nerves. While human parvovirus B19 (B19V) is a recognized rare trigger, its diagnosis can be challenging without advanced molecular techniques.", "url": "https://pubmed.ncbi.nlm.nih.gov/42243711/", "also": [] }, { "pmid": "42237532", "title": "Movement Disorders and Cerebellar Syndromes Associated with Mycoplasma pneumoniae Infection: A Systematic Review.", "journal": "Movement disorders clinical practice", "pub_date": "2026-06-04", "authors": "Garg, Ravindra Kumar, Pandey, Shweta, Jain, Amita, Karoli, Ritu et al.", "excerpt": "Mycoplasma pneumoniae is a well-recognized respiratory pathogen increasingly associated with diverse neurological manifestations beyond pulmonary disease involvement. To evaluate movement disorders and cerebellar syndromes linked to Mycoplasma pneumoniae, focusing on clinical relevance, diagnosis, and management challenges.", "url": "https://pubmed.ncbi.nlm.nih.gov/42237532/", "also": [] } ] }, "trials": [ { "nct_id": "NCT06614309", "title": "Non-invasive Treatment for Long COVID (Post COVID-19 Condition) Brain Fog", "status": "RECRUITING", "phase": "NA", "last_updated": "2026-06-05", "start_date": "2024-09-24", "sponsor": "Mayo Clinic", "sponsor_type": "OTHER", "agents": [ "Acute Progressive Carbon Dioxide", "Acute Intermittent Hypoxia", "Training: Progressive Carbon Dioxide Ramping", "Training: Intermittent Hypoxic Exposure" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06614309" }, { "nct_id": "NCT07627815", "title": "Evaluating the Safety and Efficacy of PNMR as Treatment for Long COVID", "status": "RECRUITING", "phase": "PHASE2", "last_updated": "2026-06-04", "start_date": "2026-05-20", "sponsor": "ParagonClinicals Inc.", "sponsor_type": "INDUSTRY", "agents": [ "Paragon Novel Metabolic Regulator", "Dietary And Lifestyle Recommendations" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07627815" }, { "nct_id": "NCT07621588", "title": "Diaphragmatic Breathing Exercises With KOTS Currents in Patients With Long COVID", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-06-04", "start_date": "2026-06", "sponsor": "Universidad Pontificia de Salamanca", "sponsor_type": "OTHER", "agents": [ "Diaphragmatic Electrostimulation Using Kots Currents", "Diaphragmatic Breathing Exercises" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT07621588" }, { "nct_id": "NCT06560554", "title": "Evaluating the Effects of a Fermented Diet on Microbiome Diversity in Individuals With Long COVID", "status": "ENROLLING_BY_INVITATION", "phase": "NA", "last_updated": "2026-06-03", "start_date": "2024-09-05", "sponsor": "Mayo Clinic", "sponsor_type": "OTHER", "agents": [ "Fermented Foods" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06560554" }, { "nct_id": "NCT06404112", "title": "RECOVER-SLEEP: Platform Protocol, Appendix_B (CPSD)", "status": "COMPLETED", "phase": "PHASE2", "last_updated": "2026-06-03", "start_date": "2024-07-31", "sponsor": "Duke University", "sponsor_type": "OTHER", "agents": [ "Melatonin", "Tailored Lighting (Tl) Active" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06404112" }, { "nct_id": "NCT06404099", "title": "RECOVER-SLEEP: Platform Protocol, Appendix_A (Hypersomnia)", "status": "COMPLETED", "phase": "PHASE2", "last_updated": "2026-06-03", "start_date": "2024-08-12", "sponsor": "Duke University", "sponsor_type": "OTHER", "agents": [ "Modafinil", "Solriamfetol" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06404099" }, { "nct_id": "NCT06305793", "title": "RECOVER-AUTONOMIC: Platform Protocol, Appendix A (IVIG)", "status": "ACTIVE_NOT_RECRUITING", "phase": "PHASE2", "last_updated": "2026-06-03", "start_date": "2024-03-11", "sponsor": "Kanecia Obie Zimmerman", "sponsor_type": "OTHER", "agents": [ "IVIG (Intravenous Immunoglobulin)", "Coordinated Care" ], "conditions": [ "long-covid" ], "mapped_conditions": [ "Long COVID / PASC" ], "link": "https://clinicaltrials.gov/study/NCT06305793" }, { "nct_id": "NCT07621068", "title": "Hyperbaric Oxygen Therapy for Chronic Fatigue Syndrome (CFS)", "status": "NOT_YET_RECRUITING", "phase": "NA", "last_updated": "2026-06-02", "start_date": "2026-06", "sponsor": "Assaf-Harofeh Medical Center", "sponsor_type": "OTHER_GOV", "agents": [ "Hyperbaric Oxygen Therapy (HBOT)" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT07621068" }, { "nct_id": "NCT03807973", "title": "Tracking Peripheral Immune Cell Infiltration of the Brain in Central Inflammatory Disorders Using [Zr-89]Oxinate-4-labeled Leukocytes.", "status": "SUSPENDED", "phase": "PHASE1", "last_updated": "2026-06-02", "start_date": "2021-10-05", "sponsor": "University of Alabama at Birmingham", "sponsor_type": "OTHER", "agents": [ "[Zr-89]Oxine-Labeled Leukocytes Pet/Mri" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT03807973" }, { "nct_id": "NCT03759522", "title": "Assessment of Neuroinflammation in Central Inflammatory Disorders Using [F-18]DPA-714.", "status": "RECRUITING", "phase": "PHASE1", "last_updated": "2026-06-02", "start_date": "2019-02-03", "sponsor": "University of Alabama at Birmingham", "sponsor_type": "OTHER", "agents": [ "Dpa-714 Pet/Mri" ], "conditions": [ "me-cfs" ], "mapped_conditions": [ "ME/CFS" ], "link": "https://clinicaltrials.gov/study/NCT03759522" } ], "feed_latest_pub_date": "2026-07-10", "numbers": { "studies_tracked": 544, "trials_tracked": 620, "biomarkers_catalogued": 546, "feeds": 8 }, "feed_updates": { "long-covid": "2026-07-07", "me-cfs": "2026-07-06", "pacvs": "2026-06-25", "lyme": "2026-07-08", "gulf-war-illness": "2026-07-09", "pots": "2026-07-10", "mcas": "2026-07-10", "other-post-viral": "2026-06-25" }, "trials_last_run": "2026-06-26", "generated_at": "2026-10-07T22:29:14+00:00" }