{
  "schema_version": "2.0.0",
  "id": "telechik-reunion",
  "name": "TELECHIK cohort (Réunion chikungunya)",
  "aliases": [
    "TELECHIK survey",
    "SEROCHIK/TELECHIK"
  ],
  "outbreak_event": "Réunion chikungunya outbreak 2005-06",
  "pathogen_id": "chikungunya-virus",
  "pathogen_class": "virus",
  "exposure_ascertainment": "serology",
  "design": "retrospective_cohort",
  "denominator_defined": "yes",
  "denominator_method": "Random population sample drawn from the SEROCHIK population-based serosurvey on Réunion island; participants classified by CHIKV serostatus (IgG).",
  "recruitment_source": "population_registry",
  "time_zero_definition": "Acute chikungunya infection during the 2005-06 Réunion outbreak (serologically ascertained retrospectively)",
  "time_zero_precision": "quarter",
  "control_group": "unexposed_unmatched",
  "control_matching_variables": [],
  "n_source_population": null,
  "n_enrolled": 1094,
  "n_analysed": 1094,
  "followups": [
    {
      "months": 24,
      "n_assessed": 1094,
      "n_lost": null
    }
  ],
  "max_followup_months": 34,
  "instruments": [
    "somatic-symptom-self-report"
  ],
  "case_definition": "author_defined",
  "pem_assessed": "no",
  "objective_measures": [
    "none"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum"
  ],
  "acute_phase_specimens": "no",
  "storage": null,
  "biobank_status": "unknown",
  "consent_future_use": "unknown",
  "external_access": "unknown",
  "contact": null,
  "registration_id": null,
  "funders": [
    "INSERM",
    "French Ministry of Health"
  ],
  "conflicts": null,
  "data_availability": null,
  "notes": "Population-based cohort with a seronegative comparator group (582 CHIK- vs 512 CHIK+), interviewed on average 2 years after infection (range 15-34 months, median 23.7). One of the few post-infectious cohorts with a true unexposed control drawn from the same population, allowing attributable-fraction estimation (~60% of polyarthralgia attributable to CHIKV). Ascertainment was retrospective/serological, so acute-phase data are absent.",
  "publications": [
    {
      "id": "gerardin-2011",
      "title": "Perceived morbidity and community burden after a Chikungunya outbreak: the TELECHIK survey, a population-based cohort study",
      "authors": "Gérardin P, Fianu A, Malvy D, et al.",
      "year": 2011,
      "journal": "BMC Medicine",
      "doi": "10.1186/1741-7015-9-5",
      "pmid": "21235760",
      "url": "https://pubmed.ncbi.nlm.nih.gov/21235760/",
      "open_access": true,
      "is_primary_cohort_paper": true
    },
    {
      "id": "duvignaud-2018",
      "title": "Rheumatism and chronic fatigue, the two facets of post-chikungunya disease: the TELECHIK cohort study on Reunion island",
      "authors": "Duvignaud A, Fianu A, Bertolotti A, et al.",
      "year": 2018,
      "journal": "Epidemiology and Infection",
      "doi": "10.1017/S0950268818000031",
      "pmid": "29486812",
      "url": "https://pubmed.ncbi.nlm.nih.gov/29486812/",
      "open_access": true,
      "is_primary_cohort_paper": false
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [
    {
      "id": "schilte-2013-chikungunya-reunion",
      "relation": "sibling_analysis"
    },
    {
      "id": "marimoutou-2012-gendarmes",
      "relation": "sibling_analysis"
    }
  ],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "observations": [
    {
      "id": "telechik-msk-24mo",
      "cohort_id": "telechik-reunion",
      "publication_id": "gerardin-2011",
      "schema_version": "2.0.0",
      "measure_id": "sym:arthralgia",
      "measure_verbatim": "musculoskeletal pain reported ~2 years after infection (43% in CHIKV-positive vs 17% in CHIKV-negative)",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 512
      },
      "timing": {
        "timepoint_months": 24,
        "timepoint_band": "12-24mo",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": "somatic-symptom-self-report",
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": 512,
        "percent": 43.0,
        "ci": null,
        "precision": "approximate"
      },
      "comparator": {
        "group": "unexposed_unmatched",
        "value": {
          "type": "proportion",
          "percent": 17.0,
          "precision": "exact",
          "denominator": 582
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results (musculoskeletal pain 43% in CHIK+ vs 17% in CHIK-)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    },
    {
      "id": "telechik-lrmsp-sf",
      "cohort_id": "telechik-reunion",
      "publication_id": "duvignaud-2018",
      "schema_version": "2.0.0",
      "measure_id": "sym:arthralgia",
      "measure_verbatim": "long-lasting rheumatic musculoskeletal pain",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 512
      },
      "timing": {
        "timepoint_months": 24,
        "timepoint_band": "12-24mo",
        "reference_period": "since_infection",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "structured_checklist",
        "instrument_id": "somatic-symptom-self-report",
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": 512,
        "percent": 29.9,
        "ci": null,
        "precision": "derived"
      },
      "comparator": {
        "group": "seronegative_contacts",
        "value": {
          "type": "proportion",
          "percent": 8.9,
          "precision": "exact",
          "denominator": 582
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Weighted prevalence, CHIKV+ vs CHIKV- (LRMSP 29.9% vs 8.9%)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    },
    {
      "id": "telechik-icf-sf",
      "cohort_id": "telechik-reunion",
      "publication_id": "duvignaud-2018",
      "schema_version": "2.0.0",
      "measure_id": "sym:fatigue",
      "measure_verbatim": "idiopathic chronic fatigue",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 512
      },
      "timing": {
        "timepoint_months": 24,
        "timepoint_band": "12-24mo",
        "reference_period": "since_infection",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "structured_checklist",
        "instrument_id": "somatic-symptom-self-report",
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": 512,
        "percent": 34.3,
        "ci": null,
        "precision": "derived"
      },
      "comparator": {
        "group": "seronegative_contacts",
        "value": {
          "type": "proportion",
          "percent": 12.7,
          "precision": "exact",
          "denominator": 582
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Weighted prevalence, CHIKV+ vs CHIKV- (idiopathic chronic fatigue 34.3% vs 12.7%)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    },
    {
      "id": "telechik-cfslike-sf",
      "cohort_id": "telechik-reunion",
      "publication_id": "duvignaud-2018",
      "schema_version": "2.0.0",
      "measure_id": "case-def:cfs-like",
      "measure_verbatim": "chronic fatigue syndrome-like illness",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 512
      },
      "timing": {
        "timepoint_months": 24,
        "timepoint_band": "12-24mo",
        "reference_period": "since_infection",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "structured_checklist",
        "instrument_id": "somatic-symptom-self-report",
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": 512,
        "percent": 21.5,
        "ci": null,
        "precision": "derived"
      },
      "comparator": {
        "group": "seronegative_contacts",
        "value": {
          "type": "proportion",
          "percent": 6.7,
          "precision": "exact",
          "denominator": 582
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Weighted prevalence, CHIKV+ vs CHIKV- (CFS-like illness 21.5% vs 6.7%)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    }
  ]
}