{
  "schema_version": "2.0.0",
  "id": "schilte-2013-chikungunya-reunion",
  "name": "Réunion chikungunya viremic inception cohort (Schilte)",
  "aliases": [
    "Réunion 2006 chikungunya 36-month cohort"
  ],
  "outbreak_event": "Réunion chikungunya outbreak 2005-06",
  "pathogen_id": "chikungunya-virus",
  "pathogen_class": "virus",
  "exposure_ascertainment": "pcr",
  "design": "prospective_inception",
  "denominator_defined": "partial",
  "denominator_method": "Patients with RT-PCR-confirmed acute chikungunya viraemia during the 2006 Réunion outbreak, enrolled at the acute phase and followed for 3 years.",
  "recruitment_source": "outpatient_clinic",
  "time_zero_definition": "RT-PCR-confirmed acute chikungunya viraemia",
  "time_zero_precision": "month",
  "control_group": "none",
  "control_matching_variables": [],
  "n_source_population": null,
  "n_enrolled": 180,
  "n_analysed": 180,
  "followups": [
    {
      "months": 6,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 15,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 36,
      "n_assessed": null,
      "n_lost": null
    }
  ],
  "max_followup_months": 36,
  "instruments": [
    "somatic-symptom-self-report"
  ],
  "case_definition": "author_defined",
  "pem_assessed": "no",
  "objective_measures": [
    "lab_panel"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum",
    "plasma"
  ],
  "acute_phase_specimens": "yes",
  "storage": null,
  "biobank_status": "unknown",
  "consent_future_use": "unknown",
  "external_access": "unknown",
  "contact": null,
  "registration_id": null,
  "funders": [
    "Institut Pasteur",
    "INSERM"
  ],
  "conflicts": null,
  "data_availability": null,
  "notes": "Inception cohort defined by acute RT-PCR viraemia (not just serology), with banked acute-phase specimens and 3-year follow-up of chronic arthralgia. A rarer, stronger complement to the serology-ascertained TELECHIK cohort on the same outbreak.",
  "publications": [
    {
      "id": "schilte-2013",
      "title": "Chikungunya virus-associated long-term arthralgia: a 36-month prospective longitudinal study",
      "authors": "Schilte C, Staikowsky F, Couderc T, et al.",
      "year": 2013,
      "journal": "PLoS Neglected Tropical Diseases",
      "doi": "10.1371/journal.pntd.0002137",
      "pmid": "23556021",
      "url": "https://pubmed.ncbi.nlm.nih.gov/23556021/",
      "open_access": true,
      "is_primary_cohort_paper": true
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [
    {
      "id": "telechik-reunion",
      "relation": "sibling_analysis"
    },
    {
      "id": "marimoutou-2012-gendarmes",
      "relation": "sibling_analysis"
    }
  ],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "observations": [
    {
      "id": "schilte-arthralgia-36mo",
      "cohort_id": "schilte-2013-chikungunya-reunion",
      "publication_id": "schilte-2013",
      "schema_version": "2.0.0",
      "measure_id": "sym:arthralgia",
      "measure_verbatim": "experienced chikungunya-associated arthralgia during the 3-year follow-up",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 180
      },
      "timing": {
        "timepoint_months": 36,
        "timepoint_band": "24mo+",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": "somatic-symptom-self-report",
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": 180,
        "percent": 60,
        "ci": null,
        "precision": "approximate"
      },
      "comparator": {
        "group": "none",
        "value": {
          "status": "not_applicable"
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Abstract (about 60% experienced arthralgia over 3 years)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    }
  ]
}