{
  "schema_version": "2.0.0",
  "id": "prevail-iii-ebola",
  "name": "PREVAIL III Ebola Survivor Cohort",
  "aliases": [
    "PREVAIL III",
    "Partnership for Research on Ebola Virus in Liberia III"
  ],
  "outbreak_event": "West Africa Ebola epidemic 2014–2016 (Liberia)",
  "pathogen_id": "ebola-virus",
  "pathogen_class": "virus",
  "exposure_ascertainment": "serology",
  "design": "prospective_non_inception",
  "denominator_defined": "yes",
  "denominator_method": "Ebola virus disease survivors (antibody-confirmed) and their close contacts enrolled in Liberia and followed longitudinally.",
  "recruitment_source": "mixed",
  "time_zero_definition": "Enrolment after recovery from acute Ebola virus disease",
  "time_zero_precision": "month",
  "control_group": "household_contacts",
  "control_matching_variables": [],
  "n_source_population": null,
  "n_enrolled": 1500,
  "n_analysed": 1126,
  "followups": [
    {
      "months": 6,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 12,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 60,
      "n_assessed": null,
      "n_lost": null
    }
  ],
  "max_followup_months": 60,
  "instruments": [
    "somatic-symptom-self-report"
  ],
  "case_definition": "not_applicable",
  "pem_assessed": "no",
  "objective_measures": [
    "imaging",
    "lab_panel"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum",
    "plasma",
    "other"
  ],
  "acute_phase_specimens": "no",
  "storage": "not_reported",
  "biobank_status": "active",
  "consent_future_use": "unknown",
  "external_access": "collaboration_only",
  "contact": "PREVAIL / NIAID (published study contact)",
  "registration_id": "NCT02431923",
  "funders": [
    "National Institute of Allergy and Infectious Diseases (NIAID/NIH)",
    "Liberian Ministry of Health"
  ],
  "conflicts": null,
  "data_availability": null,
  "notes": "Large observational natural-history cohort with a close-contact comparator, banked specimens, and up to 5 years of 6-monthly follow-up. Documented ocular (uveitis), musculoskeletal, neurologic and other sequelae plus viral persistence in immune-privileged sites. n_enrolled shown is the target survivor count; ~1,126 survivors enrolled by 2017 (plus ~2,700 contacts). Quantitative findings pending human extraction from source tables.",
  "publications": [
    {
      "id": "prevail-iii-2019",
      "title": "A Longitudinal Study of Ebola Sequelae in Liberia",
      "authors": "PREVAIL III Study Group",
      "year": 2019,
      "journal": "New England Journal of Medicine",
      "doi": "10.1056/NEJMoa1805435",
      "pmid": "30855742",
      "url": "https://pubmed.ncbi.nlm.nih.gov/30855742/",
      "open_access": true,
      "is_primary_cohort_paper": true
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "extensions": {
    "ebola": {
      "baseline_ocular_exam_n": 789,
      "uveitis_laterality": "not_reported"
    }
  },
  "observations": [
    {
      "id": "prevail-uveitis",
      "cohort_id": "prevail-iii-ebola",
      "publication_id": "prevail-iii-2019",
      "schema_version": "2.0.0",
      "measure_id": "func:any-persistent-symptom",
      "measure_verbatim": "uveitis (ocular sequela) significantly more prevalent among survivors than close contacts",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "unclear",
        "n_assessed": {
          "status": "measured_not_reported"
        }
      },
      "timing": {
        "timepoint_months": 6,
        "timepoint_band": "3-6mo",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": null,
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": {
          "status": "measured_not_reported"
        },
        "percent": {
          "status": "measured_not_reported"
        },
        "ci": null,
        "precision": "approximate"
      },
      "comparator": {
        "group": "none",
        "value": {
          "status": "not_applicable"
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results (uveitis among six symptoms significantly more common in survivors vs contacts; exact percentages pending extraction)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    }
  ]
}