{
  "schema_version": "2.0.0",
  "id": "mylonas-rrv-polyarthritis",
  "name": "Brisbane Ross River Virus Polyarthritis Cohort (Mylonas)",
  "aliases": [
    "Ross River virus natural history cohort"
  ],
  "outbreak_event": null,
  "pathogen_id": "ross-river-virus",
  "pathogen_class": "virus",
  "exposure_ascertainment": "serology",
  "design": "prospective_inception",
  "denominator_defined": "partial",
  "denominator_method": "Patients diagnosed with Ross River virus disease by general practitioners (clinical symptoms plus paired serology) in greater Brisbane, followed prospectively.",
  "recruitment_source": "outpatient_clinic",
  "time_zero_definition": "Diagnosis of acute Ross River virus disease",
  "time_zero_precision": "week",
  "control_group": "none",
  "control_matching_variables": [],
  "n_source_population": null,
  "n_enrolled": null,
  "n_analysed": null,
  "followups": [
    {
      "months": 1,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 2,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 3,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 6,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 12,
      "n_assessed": null,
      "n_lost": null
    }
  ],
  "max_followup_months": 12,
  "instruments": [
    "sf-36",
    "somatic-symptom-self-report"
  ],
  "case_definition": "not_applicable",
  "pem_assessed": "no",
  "objective_measures": [
    "none"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum"
  ],
  "acute_phase_specimens": "yes",
  "storage": null,
  "biobank_status": "unknown",
  "consent_future_use": "unknown",
  "external_access": "unknown",
  "contact": null,
  "registration_id": null,
  "funders": [],
  "conflicts": null,
  "data_availability": null,
  "notes": "Prospective questionnaire-based natural-history study following joint symptoms and quality of life to 12 months; showed progressive resolution over 3–6 months in most patients. Enrolled sample size not captured here (pending human extraction from the primary paper).",
  "publications": [
    {
      "id": "mylonas-2002",
      "title": "Natural history of Ross River virus-induced epidemic polyarthritis",
      "authors": "Mylonas AD, Brown AM, Carthew TL, et al.",
      "year": 2002,
      "journal": "Medical Journal of Australia",
      "pmid": "12358577",
      "url": "https://pubmed.ncbi.nlm.nih.gov/12358577/",
      "open_access": false,
      "is_primary_cohort_paper": true
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "observations": []
}