{
  "schema_version": "2.0.0",
  "id": "aucott-slice-ptlds",
  "name": "Johns Hopkins SLICE early-Lyme cohort (Aucott/Rebman)",
  "aliases": [
    "Study of Lyme Immunology and Clinical Events (SLICE)"
  ],
  "outbreak_event": null,
  "pathogen_id": "borrelia-burgdorferi",
  "pathogen_class": "bacterium",
  "exposure_ascertainment": "clinical_diagnosis",
  "design": "prospective_inception",
  "denominator_defined": "yes",
  "denominator_method": "Patients with physician-diagnosed early Lyme disease (erythema migrans), ideally treated, enrolled at diagnosis; a group of endemic-area participants without Lyme disease serves as the comparison.",
  "recruitment_source": "outpatient_clinic",
  "time_zero_definition": "Diagnosis and antibiotic treatment of early Lyme disease",
  "time_zero_precision": "week",
  "control_group": "healthy_convenience",
  "control_matching_variables": [],
  "n_source_population": null,
  "n_enrolled": 234,
  "n_analysed": 234,
  "followups": [
    {
      "months": 6,
      "n_assessed": null,
      "n_lost": null
    },
    {
      "months": 12,
      "n_assessed": null,
      "n_lost": null
    }
  ],
  "max_followup_months": 12,
  "instruments": [
    "sf-36"
  ],
  "case_definition": "author_defined",
  "pem_assessed": "no",
  "objective_measures": [
    "lab_panel"
  ],
  "specimens_collected": true,
  "specimen_types": [
    "serum",
    "plasma",
    "pbmc"
  ],
  "acute_phase_specimens": "yes",
  "storage": null,
  "biobank_status": "active",
  "consent_future_use": "disease_specific",
  "external_access": "collaboration_only",
  "contact": null,
  "registration_id": null,
  "funders": [
    "National Institutes of Health (NIAID)",
    "Steven & Alexandra Cohen Foundation"
  ],
  "conflicts": null,
  "data_availability": null,
  "notes": "Prospective inception cohort of ideally-treated early Lyme disease with a non-Lyme comparison group and a bio-repository, designed specifically to estimate the incidence of post-treatment Lyme disease. Functionally-impairing persistent symptoms occurred in 14% of treated patients vs 4% of controls, giving a rigorous denominator for PTLD that most Lyme literature lacks.",
  "publications": [
    {
      "id": "aucott-2022",
      "title": "Risk of post-treatment Lyme disease in patients with ideally-treated early Lyme disease: a prospective cohort study",
      "authors": "Aucott JN, Yang T, Yoon I, Powell D, Geller SA, Rebman AW.",
      "year": 2022,
      "journal": "International Journal of Infectious Diseases",
      "doi": "10.1016/j.ijid.2022.01.033",
      "url": "https://www.ijidonline.com/article/S1201-9712(22)00035-2/fulltext",
      "open_access": true,
      "is_primary_cohort_paper": true
    }
  ],
  "symptom_inventory_scope": "targeted_panel",
  "n_symptoms_queried": null,
  "symptom_instrument_note": null,
  "related_cohorts": [],
  "last_verified": "2026-07-20",
  "verified_by": "OSMF research-tracker (web-verified against source)",
  "harmonisation_ruleset": "pais-harmony-v1",
  "observations": [
    {
      "id": "aucott-ptld-1yr",
      "cohort_id": "aucott-slice-ptlds",
      "publication_id": "aucott-2022",
      "schema_version": "2.0.0",
      "measure_id": "func:qol-impairment",
      "measure_verbatim": "functionally-impairing persistent symptoms (post-treatment Lyme disease) after ideal treatment of early Lyme disease vs non-Lyme controls",
      "population": {
        "scope": "whole_cohort",
        "stratum": null,
        "denominator_basis": "assessed_at_timepoint",
        "n_assessed": 234
      },
      "timing": {
        "timepoint_months": 12,
        "timepoint_band": "6-12mo",
        "reference_period": "not_reported",
        "is_cumulative": false
      },
      "method": {
        "ascertainment": "unclear",
        "instrument_id": "sf-36",
        "severity_threshold": null,
        "blinded_assessment": "not_reported"
      },
      "value": {
        "type": "proportion",
        "numerator": {
          "status": "measured_not_reported"
        },
        "denominator": 234,
        "percent": 14,
        "ci": null,
        "precision": "approximate"
      },
      "comparator": {
        "group": "healthy_convenience",
        "value": {
          "type": "proportion",
          "percent": 4,
          "precision": "exact",
          "denominator": 49
        },
        "effect": null
      },
      "harmonised": null,
      "provenance": {
        "source_locator": "Results (14% of treated Lyme patients vs 4% of controls)",
        "extracted_by": null,
        "extracted_on": null,
        "verified_by": "OSMF research-tracker (web-verified against source)",
        "verified_on": "2026-07-20",
        "extraction_method": "manual"
      }
    }
  ]
}