{
  "slug": "rheumatoid-arthritis",
  "id": "rheumatoid-arthritis-biomarkers",
  "condition": {
    "name": "Rheumatoid Arthritis",
    "shortName": "Rheumatoid Arthritis",
    "alternateNames": []
  },
  "page": {
    "title": "Rheumatoid Arthritis Biomarker Atlas | Blood Tests & Molecular Alterations",
    "breadcrumbName": "Rheumatoid Arthritis Biomarkers",
    "description": "Searchable atlas of Rheumatoid Arthritis biomarkers, from peer-reviewed literature comparing patient levels vs. healthy controls.",
    "keywords": [
      "Rheumatoid Arthritis biomarkers",
      "Rheumatoid Arthritis blood tests",
      "biomarker atlas",
      "biomarker database"
    ],
    "canonical": "https://research.opensourcemed.info/rheumatoid-arthritis-biomarkers.html",
    "hero": "Molecular alterations reported in Rheumatoid Arthritis compared to healthy controls, from peer-reviewed literature.",
    "dateModified": "2026-07-03"
  },
  "categories": {
    "immune": "Immune",
    "inflammatory": "Inflammatory"
  },
  "filters": [
    "immune",
    "inflammatory"
  ],
  "markers": [
    {
      "name": "Anti-CCP Antibodies",
      "alternateName": "Anti-CCP Antibodies",
      "direction": "up",
      "category": "immune",
      "comparison": "RA vs healthy (specific marker)",
      "symptoms": "",
      "reference": {
        "citation": "Matuszewska et al. 2016",
        "doi": "10.5604/17322693.1198270"
      }
    },
    {
      "name": "CRP",
      "alternateName": "CRP",
      "direction": "up",
      "category": "inflammatory",
      "comparison": "RA vs healthy (acute phase reactant, classification criterion)",
      "symptoms": "",
      "reference": {
        "citation": "Kourilovitch et al. 2014",
        "doi": "10.1016/j.jaut.2014.01.027"
      },
      "testType": "BloodTest",
      "loinc": "1988-5"
    },
    {
      "name": "ESR",
      "alternateName": "ESR",
      "direction": "up",
      "category": "inflammatory",
      "comparison": "RA disease activity marker vs healthy baseline",
      "symptoms": "",
      "reference": {
        "citation": "Inciarte-Mundo et al. 2022",
        "doi": "10.3389/fimmu.2022.1001025"
      }
    },
    {
      "name": "IL-6",
      "alternateName": "IL-6",
      "direction": "up",
      "category": "inflammatory",
      "comparison": "RA vs healthy (established inflammatory pathway/drug target)",
      "symptoms": "",
      "reference": {
        "citation": "Qin et al. 2022",
        "doi": "10.1136/ard-2022-222605"
      },
      "testType": "BloodTest",
      "loinc": "26881-5"
    },
    {
      "name": "Rheumatoid Factor",
      "alternateName": "Rheumatoid Factor",
      "direction": "up",
      "category": "immune",
      "comparison": "RA (positive in 80-85%) vs healthy (rare)",
      "symptoms": "",
      "reference": {
        "citation": "Matuszewska et al. 2016",
        "doi": "10.5604/17322693.1198270"
      }
    }
  ]
}